Journal article
Peroxisome proliferator activated receptor-gamma and the ubiquitin-proteasome system in colorectal cancer
World journal of gastrointestinal oncology, Vol.2(5), pp.235-241
05/15/2010
DOI: 10.4251/wjgo.v2.i5.235
PMCID: PMC2998837
PMID: 21160623
Abstract
Peroxisome proliferator activated receptor-gamma ( PPAR gamma), a transcription factor of the nuclear receptor superfamily plays a significant role in colorectal cancer pathogenesis. In most experimental systems PPAR gamma activation has tumor suppressing effects in the colon. PPAR. is regulated at multiple levels by the ubiquitin-proteasome system ( UPS). At a first level, UPS regulates PPAR gamma transcription. This regulation involves both PPAR gamma transcription specific factors and the general transcription machinery. At a second level UPS regulates PPAR gamma and its co-factors themselves, as PPAR gamma and many co-factors are proteasome substrates. At a third level of regulation, transduction pathways working in parallel but also having interrelations with PPAR gamma are regulated by the UPS, creating a network of regulation in the colorectal carcinogenesisrelated pathways that are under UPS control. Activation of PPAR gamma transcription by direct pharmacologic activators and by stabilization of its molecule by proteasome inhibitors could be strategies to be exploited in colorectal cancer treatment. (C) 2010 Baishideng. All rights reserved.
Details
- Title: Subtitle
- Peroxisome proliferator activated receptor-gamma and the ubiquitin-proteasome system in colorectal cancer
- Creators
- Ioannis A. Voutsadakis - Univ Hosp Larissa, Dept Med Oncol, Larisa 41110, Greece
- Resource Type
- Journal article
- Publication Details
- World journal of gastrointestinal oncology, Vol.2(5), pp.235-241
- DOI
- 10.4251/wjgo.v2.i5.235
- PMID
- 21160623
- PMCID
- PMC2998837
- NLM abbreviation
- World J Gastrointest Oncol
- ISSN
- 1948-5204
- eISSN
- 1948-5204
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 7
- Language
- English
- Date published
- 05/15/2010
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984808091002771
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