Persistence of Individual Variations in Glycated Hemoglobin: Analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial

Darrell M WILSON; DONGYUAN XING; Eva TSALIKIAN; Howard WOLPERT; JING CHENG; Roy W BECK; Irl HIRSCH; Craig KOLLMAN; Lori LAFFEL; Jean M LAWRENCE; Nelly MAURAS; Katrina J RUEDY; Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group

doi:10.2337/dc10-1661

Back

Persistence of Individual Variations in Glycated Hemoglobin: Analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial

Journal article

Open access

Peer reviewed

Persistence of Individual Variations in Glycated Hemoglobin: Analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial

Darrell M WILSON, DONGYUAN XING, Eva TSALIKIAN, Howard WOLPERT, JING CHENG, Roy W BECK, Irl HIRSCH, Craig KOLLMAN, Lori LAFFEL, Jean M LAWRENCE, …

Diabetes care, Vol.34(6), pp.1315-1317

2011

DOI: 10.2337/dc10-1661

PMID: 21505208

Files and links (1)

url

https://doi.org/10.2337/dc10-1661View

Published (Version of record) Open Access

Abstract

OBJECTIVE To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A1c (A1C) from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring (CGM) Randomized Trial. RESEARCH DESIGN AND METHODS MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ≥4 days/week of CGM use. RESULTS Spearman correlations of the MG-to-A1C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C. CONCLUSIONS Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.

Public health. Hygiene-occupational medicine

Public health. Hygiene

Diabetes. Impaired glucose tolerance

Miscellaneous

Biological and medical sciences

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Metabolic diseases

Medical sciences

Endocrine pancreas. Apud cells (diseases)

Details

Title: Subtitle: Persistence of Individual Variations in Glycated Hemoglobin: Analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial
Creators: Darrell M WILSON - Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, California, United States
DONGYUAN XING - Jaeb Center for Health Research, Tampa, Florida, United States
Eva TSALIKIAN - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Howard WOLPERT - Adult Section, Joslin Diabetes Center, Boston, Massachusetts, United States
JING CHENG - Jaeb Center for Health Research, Tampa, Florida, United States
Roy W BECK - Jaeb Center for Health Research, Tampa, Florida, United States
Irl HIRSCH - Diabetes Care Center, University of Washington, Seattle, Washington, United States
Craig KOLLMAN - Jaeb Center for Health Research, Tampa, Florida, United States
Lori LAFFEL - Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Boston, Massachusetts, United States
Jean M LAWRENCE - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, United States
Nelly MAURAS - Division of Endocrinology and Metabolism, Nemours Children's Clinic, Jacksonville, Florida, United States
Katrina J RUEDY - Jaeb Center for Health Research, Tampa, Florida, United States
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Resource Type: Journal article
Publication Details: Diabetes care, Vol.34(6), pp.1315-1317
DOI: 10.2337/dc10-1661
PMID: 21505208
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Publisher: American Diabetes Association
Language: English
Date published: 2011
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093339302771

Metrics

14 Record Views

44 Times Cited - Web of Science