Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for Prevention of HIV-1 Mother-to-Child Transmission

Tamara S Flys; Deborah Donnell; Anthony Mwatha; Clemensia Nakabiito; Philippa Musoke; Francis Mmiro; J. Brooks Jackson; Laura A Guay; Susan H Eshleman

doi:10.1086/511433

Back

Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for Prevention of HIV-1 Mother-to-Child Transmission

Journal article

Open access

Peer reviewed

Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for Prevention of HIV-1 Mother-to-Child Transmission

Tamara S Flys, Deborah Donnell, Anthony Mwatha, Clemensia Nakabiito, Philippa Musoke, Francis Mmiro, J. Brooks Jackson, Laura A Guay and Susan H Eshleman

The Journal of infectious diseases, Vol.195(5), pp.711-715

03/01/2007

DOI: 10.1086/511433

PMID: 17262714

Files and links (1)

url

https://doi.org/10.1086/511433View

Published (Version of record) Open Access

Abstract

K103N-containing human immunodeficiency virus (HIV)-1 variants are selected in some women who receive single-dose (SD) nevirapine (NVP) for prevention of HIV-1 mother-infant transmission. We examined the persistence of K103N in women who received SD NVP prophylaxis. K103N was detected using the LigAmp assay (assay cutoff, 0.5% K103N). K103N was detected at 6-8 weeks in 60 (41.7%) of 144 women. Fading (lack of detection) of K103N was documented in 16 women by 2 years, 43 women by 3 years, and 55 women by 4 and 5 years. Slower fading was independently associated with HIV-1 subtype (D>A) and higher pre-NVP viral load.

Details

Title: Subtitle: Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for Prevention of HIV-1 Mother-to-Child Transmission
Creators: Tamara S Flys - Department of Pathology, Johns Hopkins University School of Medicine
Deborah Donnell - Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Anthony Mwatha - Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center
Clemensia Nakabiito - Department of Paediatrics Makerere University
Philippa Musoke - Department of Paediatrics Makerere University
Francis Mmiro - Obstetrics and Gynaecology, Makerere University
J. Brooks Jackson - Department of Pathology, Johns Hopkins University School of Medicine
Laura A Guay - Department of Pathology, Johns Hopkins University School of Medicine
Susan H Eshleman - Department of Pathology, Johns Hopkins University School of Medicine
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.195(5), pp.711-715
DOI: 10.1086/511433
PMID: 17262714
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: The University of Chicago Press
Language: English
Date published: 03/01/2007
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047649802771

Metrics

10 Record Views

65 Times Cited - Web of Science