Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men

Jürgen R Müller; Siegfried Janz; James J Goedert; Michael  Potter; Charles S Rabkin

doi:10.1073/pnas.92.14.6577

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Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men

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Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men

Jürgen R Müller, Siegfried Janz, James J Goedert, Michael Potter and Charles S Rabkin

Proceedings of the National Academy of Sciences - PNAS, Vol.92(14), pp.6577-6581

07/03/1995

DOI: 10.1073/pnas.92.14.6577

PMCID: PMC41561

PMID: 7604036

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Abstract

We studied blood lymphocytes of human immunodeficiency virus (HIV)-seropositive and -negative homosexual men for the presence of T(8;14) translocations that recombine c-myc and immunoglobulin heavy-chain (IgH) mu/IgH alpha switch regions. Clones with T(8;14) translocations were detected in 10.5% (12/114) of the HIV-positive and in 2.0% of the 99 uninfected patients. The majority of recombinations were found at a single time point only. Four patients, however, harbored multiple (up to four) and persistent (up to 9 years) translocation-positive cell clones. No correlation between the presence of these aberrant lymphocytes and a later lymphoma could be established. The exon 1/intron 1 region of the recombined c-myc was investigated for the presence of point mutations and these were found in the nonpersistent clones. Additional alterations detected in these clones included duplications and a deletion in the c-myc gene. The pattern of base substitution indicates that they were introduced after the translocation event.

Details

Title: Subtitle: Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men
Creators: Jürgen R Müller - Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Siegfried Janz - Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
James J Goedert - Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Michael Potter - Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Charles S Rabkin - Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.92(14), pp.6577-6581
DOI: 10.1073/pnas.92.14.6577
PMID: 7604036
PMCID: PMC41561
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 07/03/1995
Academic Unit: Pathology
Record Identifier: 9984083808802771

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