Journal article
Persistent Disease Activity in Patients With Long-Standing Glomerular Disease
Kidney international reports, Vol.5(6), pp.860-871
06/01/2020
DOI: 10.1016/j.ekir.2020.03.017
PMCID: PMC7270998
PMID: 32518868
Abstract
Introduction: Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease.
Methods: Disease activity in adults with chronic minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy (IgAN; first diagnostic biopsy >5 years before enrollment; Of Longstanding Disease [OLD] cohort, n = 256) followed at Columbia University Medical Center (CUMC), was compared with disease activity of an internal and external cohort of patients with first diagnostic biopsy <5 years before enrollment drawn from the Cure Glomerulonephropathy Network (CureGN cohort, n = 1182; CUMC-CureGN cohort, n = 362). Disease activity was defined by (i) Kidney Disease: Improving Global Outcomes-recommended threshold criteria for initiation of immunosuppression in primary glomerulonephropathy (GN) and (ii) CureGN's Disease Activity Working Group definitions for activity.
Results: No significant differences were detected among the 3 cohorts in terms of age, sex, serum creatinine, and urinary protein-to-creatinine ratio. For each GN subtype, disease activity in the OLD cohort was comparable with disease activity in the entire CureGN and the CUMC-CureGN cohort. When limiting our comparisons to disease activity in incident CUMC-CureGN patients (first diagnostic biopsy within 6 months of enrollment), OLD patients demonstrated similar activity rates as incident patients.
Conclusion: Disease activity did not differ among patients with shorter versus longer duration of disease. Such survivor patients, with long-term but persistent disease, are potentially highly informative for understanding the clinical course and pathogenesis of GN and may help identify factors mediating more chronic subtypes of disease.
Details
- Title: Subtitle
- Persistent Disease Activity in Patients With Long-Standing Glomerular Disease
- Creators
- Elisa Delbarba - Columbia University Irving Medical CenterMaddalena Marasa - Columbia University Irving Medical CenterPietro A. Canetta - Columbia University Irving Medical CenterStacy E. Piva - Columbia University Irving Medical CenterDebanjana Chatterjee - Columbia University Irving Medical CenterByum Hee Kil - Columbia University Irving Medical CenterXueru Mu - Columbia University Irving Medical CenterKeisha L. Gibson - Division of Nephrology, Department of Pediatrics, North Carolina Children’s Hospital, Chapel Hill, North Carolina, USAMichelle A. Hladunewich - Sunnybrook Health Science CentreJonathan J. Hogan - University of PennsylvaniaBruce A. Julian - University of Alabama at BirminghamJason M. Kidd - Virginia Commonwealth UniversityLouis-Philippe Laurin - Hôpital Maisonneuve-RosemontPatrick H. Nachman - University of North Carolina at Chapel HillMichelle N. Rheault - University of MinnesotaDana Rizk - University of Alabama at BirminghamNeil S. Sanghani - Vanderbilt University Medical CenterHoward Trachtman - New York UniversityScott E. Wenderfer - Texas Children's HospitalAli G. Gharavi - Columbia University Irving Medical CenterAndrew S. Bomback - Columbia University Irving Medical CenterCureGN Consortium
- Contributors
- Carla Nester (Contributor) - University of Iowa, Nephrology, Dialysis and Transplantation
- Resource Type
- Journal article
- Publication Details
- Kidney international reports, Vol.5(6), pp.860-871
- Publisher
- Elsevier
- DOI
- 10.1016/j.ekir.2020.03.017
- PMID
- 32518868
- PMCID
- PMC7270998
- ISSN
- 2468-0249
- eISSN
- 2468-0249
- Number of pages
- 12
- Grant note
- UM1DK100845; UM1DK100846; UM1DK100876; UM1DK100866; UM1DK100867 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) NephCure Kidney International
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984353824802771
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