Journal article
Persistent GB virus C infection and survival in HIV-infected men
The New England journal of medicine, Vol.350(10), pp.981-990
2004
DOI: 10.1056/NEJMoa030107
PMID: 14999110
Abstract
GB virus C (GBV-C), which is not known to be pathogenic in humans, replicates in lymphocytes, inhibits the replication of human immunodeficiency virus (HIV) in vitro, and has been associated with a decreased risk of death among HIV-positive persons in some, but not all, studies. Previous studies did not control for differences in the duration of HIV or GBV-C infection.
METHODS
We evaluated 271 men who were participants in the Multicenter Acquired Immunodeficiency Syndrome Cohort Study for GBV-C viremia (by means of a reverse-transcriptase–polymerase-chain-reaction assay) or E2 antibody (by means of an enzyme-linked immunosorbent assay) 12 to 18 months after seroconversion to positivity for HIV (the early visit); a subgroup of 138 patients was also evaluated 5 to 6 years after HIV seroconversion (the late visit).
RESULTS
GBV-C infection was detected in 85 percent of men with HIV seroconversion on the basis of the presence of E2 antibody (46 percent) or GBV-C RNA (39 percent). Only one man acquired GBV-C viremia between the early and the late visit, but 9 percent of men had clearance of GBV-C RNA between these visits. GBV-C status 12 to 18 months after HIV seroconversion was not significantly associated with survival; however, men without GBV-C RNA 5 to 6 years after HIV seroconversion were 2.78 times as likely to die as men with persistent GBV-C viremia (95 percent confidence interval, 1.34 to 5.76; P=0.006). The poorest prognosis was associated with the loss of GBV-C RNA (relative hazard for death as compared with men with persistent GBV-C RNA, 5.87; P=0.003).
CONCLUSIONS
GBV-C viremia was significantly associated with prolonged survival among HIV-positive men 5 to 6 years after HIV seroconversion, but not at 12 to 18 months, and the loss of GBV-C RNA by 5 to 6 years after HIV seroconversion was associated with the poorest prognosis. Understanding the mechanisms of interaction between GBV-C and HIV may provide insight into the progression of HIV disease.
Details
- Title: Subtitle
- Persistent GB virus C infection and survival in HIV-infected men
- Creators
- Carolyn F WILLIAMS - Epidemiology Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Md., United StatesDonna KLINZMAN - Iowa City Veterans Affairs Medical Center and University of Iowa, Iowa City, United StatesGeorg HESS - Roche Diagnostics, Mannheim, GermanyJack T STAPLETON - Iowa City Veterans Affairs Medical Center and University of Iowa, Iowa City, United StatesTraci E YAMASHITA - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United StatesJINHUA XIANG - Iowa City Veterans Affairs Medical Center and University of Iowa, Iowa City, United StatesPhilip M POLGREEN - Iowa City Veterans Affairs Medical Center and University of Iowa, Iowa City, United StatesCharles RINALDO - University of Pittsburgh Graduate School of Public Health, Pittsburgh, United StatesCHENGLONG LIU - University of California at Los Angeles, Los Angeles, United StatesJohn PHAIR - Northwestern University, Howard Brown Health Center, Chicago, United StatesJoseph B MARGOLICK - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United StatesDietmar ZDUNEK - Roche Diagnostics, Penzburg, Germany
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.350(10), pp.981-990
- DOI
- 10.1056/NEJMoa030107
- PMID
- 14999110
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 2004
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984094215902771
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