Journal article
Persistent HPV infection in postmenopausal age women
International journal of gynecology and obstetrics, Vol.87(2), pp.131-137
2004
DOI: 10.1016/j.ijgo.2004.07.013
PMID: 15491557
Abstract
Objective: Persistence of human papillomavirus (HPV) is associated with an increased risk of developing cervical SIL and cancer in young women. Because this association in older, postmenopausal age women has received little attention, we evaluated persistence of HPV among women in this age group.
Methods: Women (
n=105) ages 45–64 were examined annually for 7 years to evaluate HPV in cervical cytologic specimens. PCR, dot blot hybridization and DNA sequencing were used to detect HPV types.
Results: The cumulative prevalence of HPV was 34%, and 24% had HPV high-risk oncogenic types which are associated with genital cancers. The most common oncogenic types were HPV-16 (72%) and HPV-31 (16%). The persistence rate of HPV infection was 16%. No specific risk factors were associated with repeat viral positivity.
Conclusion: Postmenopausal women are infected with persistent oncogenic HPV at a substantial rate, supporting the need for continued screening in postmenopausal women to detect preneoplastic genital lesions.
Details
- Title: Subtitle
- Persistent HPV infection in postmenopausal age women
- Creators
- E.M Smith - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAS.R Johnson - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAJ.M Ritchie - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USAD Feddersen - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAD Wang - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAL.P Turek - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAT.H Haugen - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- International journal of gynecology and obstetrics, Vol.87(2), pp.131-137
- DOI
- 10.1016/j.ijgo.2004.07.013
- PMID
- 15491557
- NLM abbreviation
- Int J Gynaecol Obstet
- ISSN
- 0020-7292
- eISSN
- 1879-3479
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2004
- Academic Unit
- Epidemiology; Pathology; Obstetrics and Gynecology; Otolaryngology
- Record Identifier
- 9984047719102771
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