Journal article
Persistent inflammatory nociception increases levels of dynorphin1-17 in the spinal cord, but not in supraspinal nuclei involved in pain modulation
The journal of pain, Vol.3(4), pp.330-336
08/2002
DOI: 10.1054/jpai.2002.125185
PMID: 14622757
Abstract
It is well established that nerve injury or inflammatory injury results in a time-dependent increase in the expression of dynorphin in the spinal cord. However, little is known about the effects of persistent pain on the expression of this endogenous opioid peptide by supraspinal nuclei implicated in the modulation of pain sensitivity. This study used enzyme-linked immunosorbent assay to measure the levels of dynorphin1-17 in the spinal cord as well as in brainstem nuclei 4 hours, 4 days, or 2 weeks after intraplantar injection of saline or complete Freund's adjuvant in the left hind paw. As previously reported, complete Freund adjuvant produced a time-dependent increase in dynorphin that was confined to the ipsilateral dorsal horn. In contrast, levels of dynorphin1-17 in the nucleus raphe magnus, nucleus reticularis gigantocellularis pars α, parabrachial nuclei, microcellular tegmentum, pontine periaqueductal gray, and midbrain periaqueductal gray were not affected at any time after injection of complete Freund adjuvant. These data suggest that alterations in levels of dynorphin do not mediate the up-regulation of activity in bulbospinal pain inhibitory or pain facilitatory pathways that occurs during persistent pain. © 2002 by the American Pain Society
Details
- Title: Subtitle
- Persistent inflammatory nociception increases levels of dynorphin1-17 in the spinal cord, but not in supraspinal nuclei involved in pain modulation
- Creators
- Michelle C Parra - Departments of Anesthesia and Pharmacology, University of Iowa, Iowa City, IATuyet N Nguyen - Departments of Anesthesia and Pharmacology, University of Iowa, Iowa City, IARobert W Hurley - Committee on Neurobiology, University of Chicago, Chicago, ILDonna L Hammond - Departments of Anesthesia and Pharmacology, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- The journal of pain, Vol.3(4), pp.330-336
- Publisher
- Elsevier Inc
- DOI
- 10.1054/jpai.2002.125185
- PMID
- 14622757
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Language
- English
- Date published
- 08/2002
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984007289902771
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