Journal article
Persistently high glucose levels in young children with type 1 diabetes
Pediatric diabetes, Vol.17(2), pp.93-100
03/2016
DOI: 10.1111/pedi.12248
PMCID: PMC4465416
PMID: 25496062
Abstract
The aim of the study was to characterize glucose levels and variability in young children with type 1 diabetes (T1D).
A total of 144 children of 4-10 yr old diagnosed with T1D prior to age 8 were recruited at five DirecNet centers. Participants used a continuous glucose monitor (CGM) every 3 months during an 18-month study. Among the 144 participants, 135 (mean age 7.0 yr, 47% female) had a minimum of 48 h of CGM data at more than five of seven visits and were included in analyses. CGM metrics for different times of day were analyzed.
Mean hemoglobin A1c (HbA1c) at the beginning and end of the study was 7.9% (63 mmol/mol). Fifty percent of participants had glucose levels >180 mg/dL (10.0 mmol/L) for >12 h/d and >250 mg/dL (13.9 mmol/L) for >6 h/d. Median time <70 mg/dL (3.9 mmol/L) was 66 min/d and <60 mg/dL (3.3 mmol/L) was 39 min/d. Mean amplitude of glycemic excursions (MAGE) was lowest overnight (00:00-06:00 hours). The percent of CGM values 71-180 mg/dL (3.9-10.0 mmol/L) and the overall mean glucose correlated with HbA1c at all visits. There were no differences in CGM mean glucose or coefficient of variation between the age groups of 4 and <6, 6 and <8, and 8 and <10.
Suboptimal glycemic control is common in young children with T1D as reflected by glucose levels in the hyperglycemic range for much of the day. New approaches to reduce postprandial glycemic excursions and increase time in the normal range for glucose in young children with T1D are critically needed. Glycemic targets in this age range should be revisited.
Details
- Title: Subtitle
- Persistently high glucose levels in young children with type 1 diabetes
- Creators
- M Tansey - Pediatric Endocrinology, University of Iowa, Iowa City, IA, USAR Beck - Jaeb Center for Health Research, Tampa, FL, USAK Ruedy - Jaeb Center for Health Research, Tampa, FL, USAW Tamborlane - Pediatric Endocrinology, Yale University, New Haven, CT, USAP Cheng - Jaeb Center for Health Research, Tampa, FL, USAC Kollman - Jaeb Center for Health Research, Tampa, FL, USAL Fox - Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FL, USAS Weinzimer - Pediatric Endocrinology, Yale University, New Haven, CT, USAN Mauras - Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FL, USAN H White - Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USAE Tsalikian - Pediatric Endocrinology, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Pediatric diabetes, Vol.17(2), pp.93-100
- DOI
- 10.1111/pedi.12248
- PMID
- 25496062
- PMCID
- PMC4465416
- NLM abbreviation
- Pediatr Diabetes
- ISSN
- 1399-543X
- eISSN
- 1399-5448
- Publisher
- Wiley; Denmark
- Grant note
- U01 HD41890 / NICHD NIH HHS HD41908 / NICHD NIH HHS R01 HD078463 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS UL1 TR000448 / NCATS NIH HHS U10 HD041918 / NICHD NIH HHS HD56526 / NICHD NIH HHS HD41906 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD41918 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS HD41915 / NICHD NIH HHS UL1 RR024992 / NCRR NIH HHS U10 HD056526 / NICHD NIH HHS P30 DK045735 / NIDDK NIH HHS U01 HD041890 / NICHD NIH HHS
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics
- Record Identifier
- 9984065389502771
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