Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

Michelle M Martel; Molly Nikolas; Katherine Jernigan; Karen Friderici; Joel T Nigg

doi:10.1007/s10802-010-9392-3

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Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

Journal article

Peer reviewed

Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

Michelle M Martel, Molly Nikolas, Katherine Jernigan, Karen Friderici and Joel T Nigg

Journal of abnormal child psychology, Vol.38(5), pp.633-643

07/2010

DOI: 10.1007/s10802-010-9392-3

PMCID: PMC4303410

PMID: 20146095

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https://www.ncbi.nlm.nih.gov/pmc/articles/4303410View

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Abstract

Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multistage diagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.

Disruptive behaviors

ADHD

Genetics

Personality

Details

Title: Subtitle: Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder
Creators: Michelle M Martel - Psychology Department, University of New Orleans, 2000 Lakeshore Drive; 2005 Geology & Psychology Building, New Orleans, LA 70148, USA
Molly Nikolas - Psychology Department, Michigan State University, East Lansing, MI, USA
Katherine Jernigan - Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
Karen Friderici - Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA
Joel T Nigg - Psychiatry Department, Oregon Health and Sciences University, Portland, OR, USA
Resource Type: Journal article
Publication Details: Journal of abnormal child psychology, Vol.38(5), pp.633-643
DOI: 10.1007/s10802-010-9392-3
PMID: 20146095
PMCID: PMC4303410
NLM abbreviation: J Abnorm Child Psychol
ISSN: 0091-0627
eISSN: 1573-2835
Language: English
Date published: 07/2010
Academic Unit: Psychological and Brain Sciences; Injury Prevention Research Center
Record Identifier: 9984002469502771

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