Journal article
Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report
Oncology letters, Vol.27(6), p.282
06/01/2024
DOI: 10.3892/ol.2024.14415
PMCID: PMC11082640
PMID: 38736743
Abstract
The detection of circulating tumor DNA (ctDNA) in the plasma of cancer patients is emerging as a very sensitive and specific prognostic biomarker. Previous studies with ctDNA have focused on the ability of ctDNA detection to predict micrometastatic and eventual clinical metastatic relapse. There are few data on the role of ctDNA in monitoring response to local therapy. The present study reports the case of a patient with early-stage lobular breast cancer, with a detectable ctDNA test which resolved with local radiotherapy to the breast. This case suggests that ctDNA is sensitive enough to detect the response of minimal residual disease, localized in the breast, to radiation therapy, and thus may assist in providing indications for local breast cancer treatment.
Details
- Title: Subtitle
- Personalized circulating tumor DNA response to local radiotherapy in a patient with an early lobular breast cancer: A case report
- Creators
- Mariana Pilon Capella - Jewish General HospitalParvaneh Fallah - Jewish General HospitalMark Basik - McGill University
- Resource Type
- Journal article
- Publication Details
- Oncology letters, Vol.27(6), p.282
- DOI
- 10.3892/ol.2024.14415
- PMID
- 38736743
- PMCID
- PMC11082640
- NLM abbreviation
- Oncol Lett
- ISSN
- 1792-1074
- eISSN
- 1792-1082
- Publisher
- Spandidos Publ Ltd
- Number of pages
- 5
- Language
- English
- Date published
- 06/01/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984945920202771
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