Journal article
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Cell, Vol.173(2), pp.305-320.e10
04/05/2018
DOI: 10.1016/j.cell.2018.03.033
PMCID: PMC5916814
PMID: 29625049
Abstract
The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.
Details
- Title: Subtitle
- Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
- Creators
- Li Ding - Washington University in St. LouisMatthew H Bailey - Washington University in St. LouisEduard Porta-Pardo - Sanford Burnham Prebys Medical Discovery InstituteVesteinn Thorsson - Institute for Systems BiologyAntonio Colaprico - Université Libre de BruxellesDenis Bertrand - Genome Institute of SingaporeDavid L Gibbs - Institute for Systems BiologyAmila Weerasinghe - Washington University in St. LouisKuan-Lin Huang - Washington University in St. LouisCollin Tokheim - Johns Hopkins UniversityIsidro Cortés-Ciriano - University of CambridgeReyka Jayasinghe - Washington University in St. LouisFeng Chen - Washington University in St. LouisLihua Yu - H3 Biomedicine Inc., Cambridge, MA 02139, USA.Sam Sun - Baylor College of MedicineCatharina Olsen - Université Libre de BruxellesJaegil Kim - Broad InstituteAlison M Taylor - Harvard UniversityAndrew D Cherniack - Broad InstituteRehan Akbani - The University of Texas MD Anderson Cancer CenterChayaporn Suphavilai - Genome Institute of SingaporeNiranjan Nagarajan - Genome Institute of SingaporeJoshua M Stuart - University of California, Santa CruzGordon B Mills - The University of Texas MD Anderson Cancer CenterMatthew A Wyczalkowski - Washington University in St. LouisBenjamin G Vincent - University of North Carolina at Chapel HillCarolyn M Hutter - National Institutes of HealthJean Claude Zenklusen - National Cancer InstituteKatherine A Hoadley - University of North Carolina at Chapel HillMichael C Wendl - Washington University in St. LouisLlya Shmulevich - Institute for Systems BiologyAlexander J Lazar - The University of Texas MD Anderson Cancer CenterDavid A Wheeler - Baylor College of MedicineGad Getz - Broad Institute
- Contributors
- Cancer Genome Atlas Research Network (Contributor)Deqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.173(2), pp.305-320.e10
- DOI
- 10.1016/j.cell.2018.03.033
- PMID
- 29625049
- PMCID
- PMC5916814
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Grant note
- U24 CA143843 / NCI NIH HHS P30 CA016086 / NCI NIH HHS U24 CA210957 / NCI NIH HHS U54 HG003079 / NHGRI NIH HHS P30 CA016672 / NCI NIH HHS P30 ES010126 / NIEHS NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS U24 CA210988 / NCI NIH HHS R50 CA221675 / NCI NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U24 CA210974 / NCI NIH HHS U24 CA143882 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA143840 / NCI NIH HHS U24 CA211006 / NCI NIH HHS R25 DA027995 / NIDA NIH HHS U24 CA144025 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA210949 / NCI NIH HHS U24 CA143848 / NCI NIH HHS R01 CA163722 / NCI NIH HHS
- Language
- English
- Date published
- 04/05/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984185171702771
Metrics
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