Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)

Herbert B Tanowitz; Fabiana S Machado; Linda A Jelicks; Jamshid Shirani; Antonio C Campos de Carvalho; David C Spray; Stephen M Factor; Louis V Kirchhoff; Louis M Weiss

doi:10.1016/j.pcad.2009.02.001

Back

Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)

Journal article

Open access

Peer reviewed

Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)

Herbert B Tanowitz, Fabiana S Machado, Linda A Jelicks, Jamshid Shirani, Antonio C Campos de Carvalho, David C Spray, Stephen M Factor, Louis V Kirchhoff and Louis M Weiss

Progress in cardiovascular diseases, Vol.51(6), pp.524-539

05/2009

DOI: 10.1016/j.pcad.2009.02.001

PMCID: PMC2677559

PMID: 19410685

View Online

Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi. It is a common cause of heart disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of the discovery of T cruzi infection and Chagas disease by the Brazilian physician Carlos Chagas. Chagasic cardiomyopathy develops in from 10% to 30% of persons who are chronically infected with this parasite. Echocardiography and magnetic resonance imaging (MRI) are important modalities in the evaluation and prognostication of individuals with chagasic heart disease. The etiology of chagasic heart disease likely is multifactorial. Parasite persistence, autoimmunity, and microvascular abnormalities have been studied extensively as possible pathogenic mechanisms. Experimental studies suggest that alterations in cardiac gap junctions may be etiologic in the pathogenesis of conduction abnormalities. The diagnosis of chronic Chagas disease is made by serology. The treatment of this infection has shortcomings that need to be addressed. Cardiac transplantation and bone marrow stem cell therapy for persons with Chagas disease have received increasing research attention in recent years.

Animals

Brazil

Chagas Cardiomyopathy - diagnostic imaging

Chagas Cardiomyopathy - epidemiology

Chagas Cardiomyopathy - immunology

Chagas Cardiomyopathy - parasitology

Chagas Cardiomyopathy - pathology

Chagas Disease - epidemiology

Chagas Disease - parasitology

Endemic Diseases - prevention & control

Endemic Diseases - statistics & numerical data

History, 19th Century

History, 20th Century

Humans

Life Cycle Stages

Magnetic Resonance Imaging

Muscle Cells - parasitology

South America - epidemiology

Trypanosoma cruzi - growth & development

Ultrasonography

Details

Title: Subtitle: Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)
Creators: Herbert B Tanowitz - Albert Einstein College of Medicine
Fabiana S Machado - Albert Einstein College of Medicine
Linda A Jelicks - Albert Einstein College of Medicine
Jamshid Shirani - Albert Einstein College of Medicine
Antonio C Campos de Carvalho
David C Spray - Albert Einstein College of Medicine
Stephen M Factor - Albert Einstein College of Medicine
Louis V Kirchhoff - Albert Einstein College of Medicine
Louis M Weiss - Albert Einstein College of Medicine
Resource Type: Journal article
Publication Details: Progress in cardiovascular diseases, Vol.51(6), pp.524-539
DOI: 10.1016/j.pcad.2009.02.001
PMID: 19410685
PMCID: PMC2677559
NLM abbreviation: Prog Cardiovasc Dis
ISSN: 0033-0620
eISSN: 1873-1740
Grant note: HL-73732 / NHLBI NIH HHS AI-076248 / NIAID NIH HHS R01 HL073732-03 / NHLBI NIH HHS R01 HL073732 / NHLBI NIH HHS D43 TW007129-07 / FIC NIH HHS D43 TW007129 / FIC NIH HHS R01 AI076248-02 / NIAID NIH HHS R01 AI076248 / NIAID NIH HHS R01 HL073732-07 / NHLBI NIH HHS R01 HL073732-05A1 / NHLBI NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9984280870202771

Metrics

25 Record Views

122 Times Cited - Web of Science

See more details