Journal article
Perspectives on chondrocyte mechanobiology and osteoarthritis
Biorheology (Oxford), Vol.43(3,4), pp.603-609
2006
PMID: 16912432
Abstract
Osteoarthritis, the clinical syndrome of joint pain and dysfunction due to joint degeneration, is among the most frequent and symptomatic medical problems for middle aged and older people, and it is the most common cause of long term disability in most populations of people over 65. Currently there are no effective methods of preventing or curing osteoarthritis. Post-traumatic OA, the joint degeneration, pain and dysfunction that develop following joint injury, is the form of OA that is most directly related to elevated articular surface contact stress. However, mechanical stress that exceeds the tolerance of the articular surface can cause or accelerate the progression of joint degeneration in all individuals and in all synovial joints. In some patients, decreasing mechanical forces on degenerated joint surfaces stimulates formation of a new biologic articular surface. The advances in understanding of the effects of mechanical forces on chondrocytes and cartilage presented and discussed at the 4th Symposium on Mechanobiology: Cartilage and Chondrocyte will help in the efforts to develop new methods of preventing and treating osteoarthritis.
Details
- Title: Subtitle
- Perspectives on chondrocyte mechanobiology and osteoarthritis
- Creators
- Joseph A Buckwalter - University of Iowa, Department of Orthopaedics and Rehabilitation, Iowa City, IA 52242, USA. joseph-buckwalter@uiowa.eduJames A MartinThomas D Brown
- Resource Type
- Journal article
- Publication Details
- Biorheology (Oxford), Vol.43(3,4), pp.603-609
- PMID
- 16912432
- NLM abbreviation
- Biorheology
- ISSN
- 0006-355X
- eISSN
- 1878-5034
- Publisher
- Netherlands
- Grant note
- P50 AR48939 / NIAMS NIH HHS
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Injury Prevention Research Center
- Record Identifier
- 9984040574702771
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