Logo image
IRO Home Research units Researcher Profiles
Sign in
Pestaloporonins: Caryophyllene-Derived Sesquiterpenoids from a Fungicolous Isolate of Pestalotiopsis sp
Journal article   Peer reviewed

Pestaloporonins: Caryophyllene-Derived Sesquiterpenoids from a Fungicolous Isolate of Pestalotiopsis sp

In Hyun Hwang, Dale C Swenson, James B Gloer and Donald T Wicklow
Organic letters, Vol.17(17), pp.4284-4287
09/04/2015
DOI: 10.1021/acs.orglett.5b02080
PMID: 26287562

View Online

Abstract

Three new sesquiterpenoids (pestaloporonins A-C; 1-3) related to the caryophyllene-derived punctaporonins were isolated from cultures of a fungicolous isolate of Pestalotiopsis sp. The structures of 1-3 were determined by analysis of NMR and HRMS data, and the structure of 1, including its absolute configuration, was confirmed by X-ray crystallographic analysis. Compounds 1 and 2 contain new bicyclic and tricyclic ring systems, respectively.
Sesquiterpenes - isolation & purification Sesquiterpenes - chemistry HCT116 Cells Humans Crystallography, X-Ray Structure-Activity Relationship Microbial Sensitivity Tests Nuclear Magnetic Resonance, Biomolecular Molecular Structure HeLa Cells Sesquiterpenes - pharmacology Staphylococcus aureus - drug effects Xylariales - chemistry Drug Screening Assays, Antitumor

Details

Metrics

Logo image