Journal article
Pharmacodynamic response to warfarin after conversion of atrial fibrillation or flutter to sinus rhythm
American journal of health-system pharmacy, Vol.69(13), pp.1158-1161
07/01/2012
DOI: 10.2146/ajhp110609
PMID: 22722595
Abstract
Purpose. The results of an evaluation of the impact of restoring sinus rhythm on warfarin sensitivity are reported.
Methods. A retrospective review of the records of all patients (n = 46) with atrial fibrillation or flutter who underwent car-dioversion or ablation procedures to restore sinus rhythm at a large medical center during a 27-month period was conducted. Patient data covering the 3-month periods before and after the procedures were reviewed to identify the warfarin doses required to maintain International Normalized Ratio (INR) values in the recommended range of 2.0-3.0. Within-individual preprocedure and postprocedure mean weekly warfarin doses for two periods (zero to four weeks and an expanded period of four weeks-3 months) were compared using paired t tests.
Results. The average weekly warfarin dose during the four-week preprocedure period was not significantly different from the doses during the four-week and expanded postprocedure periods. The average weekly doses during the four-week and expanded postprocedure periods were significantly less than those used in the expanded preprocedure period (p = 0.004 and p = 0.046, respectively).
Conclusion. Warfarin dosages required to maintain a goal INR of 2.0-3.0 were relatively stable in the four weeks before and after procedures to convert atrial fibrillation or flutter to sinus rhythm. Changes in the weekly warfarin dose requirement of >= 10% after the procedures were implemented in a small proportion of patients. The mean weekly warfarin dose was significantly lower in the three months after than in the three months before the procedure. Am J Health-Syst Pharm. 2012; 69:1158-61
Details
- Title: Subtitle
- Pharmacodynamic response to warfarin after conversion of atrial fibrillation or flutter to sinus rhythm
- Creators
- Melissa C. Staats - University of IowaMichael E. Ernst - Places For People
- Resource Type
- Journal article
- Publication Details
- American journal of health-system pharmacy, Vol.69(13), pp.1158-1161
- Publisher
- Oxford Univ Press
- DOI
- 10.2146/ajhp110609
- PMID
- 22722595
- ISSN
- 1079-2082
- eISSN
- 1535-2900
- Number of pages
- 4
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297452002771
Metrics
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