Journal article
Pharmacogenetics and Schizophrenia
Clinics in laboratory medicine, Vol.30(4), pp.975-993
2010
DOI: 10.1016/j.cll.2010.07.010
PMID: 20832661
Abstract
The wide interindividual variability in clinical response and tolerability of antipsychotic medications has led investigators to postulate that these variabilities may be under genetic control. Although not always consistent, there are promising indications from emergent pharmacogenetic studies that efficacy of antipsychotic medications for the various symptom domains of psychopathology in schizophrenia may be genetically regulated. This is an encouraging approach. Moreover, there are also suggestive findings that the side-effect profiles of second-generation antipsychotic medications and their propensity to cause weight gain and glucose and lipid abnormalities as well as tardive dyskinesia may be related to pharmacogenetic factors in this patient population. Ultimately, such approaches could drive choices of antipsychotic medication based on the likelihood of clinical response and development of side effects in light of a particular patient's genetic profile. In the future, this targeted approach (personalized medicine) may become informative for clinicians choosing an antipsychotic medication for an individual patient with schizophrenia.
Details
- Title: Subtitle
- Pharmacogenetics and Schizophrenia
- Creators
- Adriana Foster - Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 St Sebastian, Augusta, GA 30912, USADel D Miller - Department of Psychiatry, University of Iowa Carver College of Medicine, #2-105 Medical Education Building, 500 Newton Road, Iowa City, IA 52242-1000, USAPeter Buckley - Department of Psychiatry and Health Behavior, Medical College of Georgia, 997 St Sebastian, Augusta, GA 30912, USA
- Resource Type
- Journal article
- Publication Details
- Clinics in laboratory medicine, Vol.30(4), pp.975-993
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cll.2010.07.010
- PMID
- 20832661
- ISSN
- 0272-2712
- eISSN
- 1557-9832
- Language
- English
- Date published
- 2010
- Academic Unit
- Psychiatry
- Record Identifier
- 9984004089002771
Metrics
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