Journal article
Pharmacokinetics and Echocardiographic Effects of Digoxin in Low Birth Weight Infants with Left-to-Right Shunting due to Patent Ductus arteriosus
Developmental pharmacology and therapeutics, Vol.1(2-3), pp.189-200
1980
DOI: 10.1159/000455535
PMID: 6927548
Abstract
Serum digoxin (DIG) levels, timed urine and M-mode echocardiograms were performed in 9 low birth weight infants with left-to-right shunting due to patent ductus arteriosus treated 18, DIG (40 μg/kg in 3 and 20 μg/kg in 6). Half the DIG was given initially and a quarter at 8-hourly intervals. Serum DIG levels at 24 h (1.8-7.0 ng/ml) were similar in both dose groups. One infant in the 40 μg/kg dose group developed Wenckebach phenomenon. Left atrial to aortic root ratio fell within 30 min and remained reduced during the ensuing 24 h (p < 0.025). There were no significant changes in the other echocardiographic measurements. Half-life of distribution and elimination of DIG were 1.04 ± 0.46 and 15.25 ± 0.36 h. The α-phase volumes of distribution (VD) differed between the 40 and 20 μg/kg dose groups (2.28 ± 0.05 vs. 1.33 ± 0.66 liters/kg, p < 0.025). The β-phase VD (4.25 ± 0.61 and 2.76 ± 0.99, respectively) were similar. Mean urinary DIG clearance was 13.1 ± 3.2 ml/min/1.73 m2.
Details
- Title: Subtitle
- Pharmacokinetics and Echocardiographic Effects of Digoxin in Low Birth Weight Infants with Left-to-Right Shunting due to Patent Ductus arteriosus
- Creators
- David WarburtonEdward F. BellWilliam Oh
- Resource Type
- Journal article
- Publication Details
- Developmental pharmacology and therapeutics, Vol.1(2-3), pp.189-200
- DOI
- 10.1159/000455535
- PMID
- 6927548
- ISSN
- 0379-8305
- eISSN
- 2504-2505
- Language
- English
- Date published
- 1980
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353773002771
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