Journal article
Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl
Anesthesia and analgesia, Vol.103(4), pp.815-821
10/2006
DOI: 10.1213/01.ane.0000237284.30817.f6
PMID: 17000787
Abstract
BACKGROUND:
We investigated the involvement of central and peripheral opioid receptors (OR) in the cardioprotective effects of fentanyl (FENT) in a model of myocardial ischemia/reperfusion injury associated with pharmacologically induced sympathetic overactivity in anesthetized rabbits.
METHODS:
Central sympathetic stimulation was achieved through intracerebroventricular injection of l-glutamate in animals submitted to 35 min of coronary occlusion followed by 120 min of reperfusion. Rabbits received naloxone HCl intracerebroventricularly or naloxone methiodide IV, a quaternary compound that does not cross the blood–brain barrier, 5 min before FENT treatment (5 or 50 μg/kg, IV).
RESULTS:
Infarct area was reduced only by FENT 50 (from 51% ± 2% to 24% ± 2%). This protective effect was abolished by peripheral (42% ± 4%), but not central, OR blockade (32% ± 3%). The number of premature ventricular complexes during the ischemic period (54 ± 3) was reduced by FENT 50 (19 ± 7), an effect blunted by central (40 ± 3) but not peripheral (18 ± 7) blockade of OR. During reperfusion, the number of premature ventricular complexes (134 ± 50) was reduced to 9 ± 5 by FENT 50 and was prevented by central (42 ± 4) as well as peripheral (20 ± 11) OR blockade. The mortality rate (50%) and incidence of ventricular tachycardia (55%) were completely abolished by FENT 50.
CONCLUSIONS:
We conclude that fentanyl's effects for limiting myocardial ischemic injury are mediated via peripheral ORs while opioid's antiarrhythmic actions are mediated via central OR agonism.
Details
- Title: Subtitle
- Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl
- Creators
- Marcos A Lessa - University of Iowa, AnesthesiaEduardo Tibirica - Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- Anesthesia and analgesia, Vol.103(4), pp.815-821
- DOI
- 10.1213/01.ane.0000237284.30817.f6
- PMID
- 17000787
- NLM abbreviation
- Anesth Analg
- ISSN
- 0003-2999
- eISSN
- 1526-7598
- Publisher
- Lippincott
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Anesthesia
- Record Identifier
- 9984656527302771
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