Journal article
Pharmacological Treatment for Heart Failure: A View From the Brain
Clinical pharmacology and therapeutics, Vol.86(2), pp.216-220
08/2009
DOI: 10.1038/clpt.2009.117
PMCID: PMC2786214
PMID: 19553933
Abstract
Systolic heart failure is a feed‐forward phenomenon with devastating consequences. Impaired cardiac function is the initiating event, but central nervous system mechanisms activated by persistent altered neural and humoral signals from the periphery play an important sustaining role. Animals with experimentally induced heart failure have neurochemical abnormalities in the brain that, when manipulated, profoundly affect sympathetic drive, volume regulation, and cardiac remodeling—critical determinants of outcome. This brief review explores recent studies that provide a strong rationale for the development of pharmaceutical agents that target central nervous system abnormalities in heart failure.
Clinical Pharmacology & Therapeutics (2009); 86, 2, 216–220 doi:10.1038/clpt.2009.117
Details
- Title: Subtitle
- Pharmacological Treatment for Heart Failure: A View From the Brain
- Creators
- R B Felder - University of IowaY Yu - University of IowaZ‐H Zhang - University of IowaS‐G Wei - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.86(2), pp.216-220
- DOI
- 10.1038/clpt.2009.117
- PMID
- 19553933
- PMCID
- PMC2786214
- NLM abbreviation
- Clin Pharmacol Ther
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 5
- Language
- English
- Date published
- 08/2009
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065392002771
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