Journal article
Pharmacological alteration of the lung vascular response to radiation
International journal of radiation oncology, biology, physics, Vol.19(2), pp.329-339
1990
DOI: 10.1016/0360-3016(90)90541-Q
PMID: 2168354
Abstract
The role of endothelial cell damage in the development of radiation injury in the lung was investigated in rats. Vascular permeability-surface area product (PS) was measured as an indicator of the degree of endothelial cell damage in lungs of rats exposed to single dose hemithorax irradiation. Hemithorax irradiation was chosen to simulate clinical radiotherapy, in which only a portion of the lung is irradiated. In addition, it provided a control lung to compare to the irradiated lung. Radiation is postulated to lead to activation of several different biochemical pathways that result in lung injury and fibrosis. Many of these pathways can be specifically blocked with drugs. Thirteen different drugs were studied. Dexamethasone, indomethacin, cromolyn, cyproheptadine, Vitamin D
3, theophylline, and diethylcarbamazine were all effective at reducing lung PS on the irradiated side. Dexamethasone, Vitamin D
3, and iindomethacin also significantly reduced lung PS in the unirradiated lungs and in sham-irradiated rats. Captopril, cobra venom factor, penicillamine, trapidil, epsilon-amino caproic acid, and dapsone had no significant effect on lung PS after hemithorax irradiation. We conclude that the major pathways involved in early post-radiation lung injury involve; prostaglandin, leukotriene, and histamine release from macrophages and mast cells. Complement activation, proteolytic enzymes, and neutrophil migration do not seem to be important mediators of early postradiation lung injury.
Details
- Title: Subtitle
- Pharmacological alteration of the lung vascular response to radiation
- Creators
- Michael M Graham - Department of Radiation Oncology, University of Washington, Seattle, WA, USAMargaret L Evans - Department of Radiation Oncology, University of Washington, Seattle, WA, USADebra D Dahlen - Department of Radiation Oncology, University of Washington, Seattle, WA, USAPeter A Mahler - Department of Human Oncology, University of Wisconsin, Madison, WI, USAJanet S Rasey - Department of Radiation Oncology, University of Washington, Seattle, WA, USA
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.19(2), pp.329-339
- DOI
- 10.1016/0360-3016(90)90541-Q
- PMID
- 2168354
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1990
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984046919402771
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