Pharmacological comparison of endothelium-dependent relaxation in isolated cerebral and extracerebral arteries

Tadayoshi Nakagomi; Kazuhiro Hongo; Neal F Kassell; Tomio Sasaki; R Michael Lehman; Hisayuki Ogawa; Dennis G Vollmer; James C Torner

doi:10.3171/jns.1988.69.4.0580

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Pharmacological comparison of endothelium-dependent relaxation in isolated cerebral and extracerebral arteries

Journal article

Peer reviewed

Pharmacological comparison of endothelium-dependent relaxation in isolated cerebral and extracerebral arteries

Tadayoshi Nakagomi, Kazuhiro Hongo, Neal F Kassell, Tomio Sasaki, R Michael Lehman, Hisayuki Ogawa, Dennis G Vollmer and James C Torner

Journal of neurosurgery, Vol.69(4), pp.580-587

10/1988

DOI: 10.3171/jns.1988.69.4.0580

PMID: 3418391

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Abstract

Endothelium-dependent relaxation was induced by acetylcholine (ACh), adenosine triphosphate (ATP), and thrombin in isolated cerebral and extracerebral arteries obtained from rabbits and dogs. Using an isometric tension-recording method, the authors then examined the difference in the extent of relaxation between the cerebral and extracerebral arteries. In rabbits, the dose-response curve of the basilar artery for ACh was significantly different (p less than 0.05) from curves of the femoral and common carotid arteries. The IC50 value (the concentration inducing a one-half inhibition of the initial contractile tone) for the basilar artery in ACh-induced relaxation was significantly higher (p less than 0.05) than for the common carotid artery, although the mean maximum relaxation of the basilar artery to ACh was not significantly different from that seen in extracerebral arteries. The relaxing effect of ACh in dogs was much less in the middle cerebral and basilar arteries than in the common carotid, vertebral, and femoral arteries. On the other hand, both ATP (in rabbits and dogs) and thrombin (in dogs) induced significantly more (p less than 0.05) relaxation in the cerebral arteries than in the extracerebral arteries. Endothelium-dependent relaxation induced by ACh or ATP has been demonstrated in a wide range of arteries from a variety of animals. The present results suggest that ATP has a more important role than ACh in the regulation of the vascular tone of the major cerebral arteries in these two species.

Rabbits

Acetylcholine - pharmacology

Vasoconstriction

Male

Cerebral Arteries - physiology

Femoral Artery - drug effects

Serotonin - pharmacology

Endothelium, Vascular - physiology

Adenosine Triphosphate - pharmacology

Cerebral Arteries - drug effects

Dose-Response Relationship, Drug

Animals

Thrombin - pharmacology

Dogs

Female

Femoral Artery - physiology

Vasodilation - drug effects

In Vitro Techniques

Details

Title: Subtitle: Pharmacological comparison of endothelium-dependent relaxation in isolated cerebral and extracerebral arteries
Creators: Tadayoshi Nakagomi - Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville
Kazuhiro Hongo
Neal F Kassell
Tomio Sasaki
R Michael Lehman
Hisayuki Ogawa
Dennis G Vollmer
James C Torner
Resource Type: Journal article
Publication Details: Journal of neurosurgery, Vol.69(4), pp.580-587
DOI: 10.3171/jns.1988.69.4.0580
PMID: 3418391
NLM abbreviation: J Neurosurg
ISSN: 0022-3085
eISSN: 1933-0693
Publisher: United States
Language: English
Date published: 10/1988
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995104202771

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