Pharmacological modulation of wound healing in experimental burns

Abdo Jurjus; Bishara S Atiyeh; Inaya M Abdallah; Rosalyne A Jurjus; Shady N Hayek; Marlene Abou Jaoude; Alice Gerges; Rania A. Tohme

doi:10.1016/j.burns.2006.10.406

Factors involved in wound healing and their interdependence are not yet fully understood; nevertheless, new prospects for therapy to favor speedy and optimal healing are emerging. Reports about wound healing modulation by local application of simple and natural agents abound even in the recent literature, however, most are anecdotal and lack solid scientific evidence. We describe the effect of silver sulfadiazine and moist exposed burn ointment (MEBO), a recently described burn ointment of herbal origin, on mast cells and several wound healing cytokines (bFGF, IL-1, TGF-β, and NGF) in the rabbit experimental burn model. The results demonstrate that various inflammatory cells, growth factors and cytokines present in the wound bed may be modulated by application of local agents with drastic effects on their expression dynamics with characteristic temporal and spatial regulation and changes in the expression pattern. Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens. © 2006 Elsevier Ltd and ISBI. Abd-El-Aleem SA, 2005, EUR J HISTOCHEM, V49, P265; Abraham J. A., 1996, MOL CELLULAR BIOL WO, P195; Abraham SN, 1997, INFECT IMMUN, V65, P3501; Acikel C, 2003, J BURN CARE REHABIL, V24, P37, DOI 10.1097-01.BCR.0000045650.32637.CE; Aloe L, 2004, PROG BRAIN RES, V146, P515; Amendt C, 2002, J CELL SCI, V115, P2189; ANAND O, 1996, NAT MED, V6, P703; Angele MK, 1999, SURGERY, V126, P279, DOI 10.1067-msy.1999.98743; APFEL SC, 1994, BRAIN RES, V634, P7, DOI 10.1016-0006-8993(94)90252-6; Atiyeh BS, 2005, WORLD J SURG, V29, P131, DOI 10.1007-s00268-004-1082-2; ATIYEH BS, 2004, MED CHEM REV, V1, P111, DOI 10.2174-1567203043480304; ATIYEH BS, 2003, INDIAN J PLAST SURG, V36, P89; Atiyeh BS, 2003, EUR J PLAST SURG, V26, P5; Atiyeh BS, 2005, BURNS, V31, P944, DOI 10.1016-j.burns.2005.08.023; Atiyeh BS, 2003, DERMATOL SURG, V29, P14, DOI 10.1046-j.1524-4725.2003.29002.x; ATIYEH BS, 2003, J BURNS SURG WOUND C, V2, P18; Atiyeh BS, 2003, AESTHET PLAST SURG, V27, P411, DOI 10.1007-s00266-003-3049-3; ATIYEH BS, 2005, J PLAIES CICATRISATI, V49, P7; Awane M, 1999, J IMMUNOL, V162, P5337; BEANES SR, 2003, EXPERT REV MOL MED, P1; Beanes Steven R., 2003, Expert Reviews in Molecular Medicine, V5, P1; Bernabei R, 1999, LANCET, V354, P307, DOI 10.1016-S0140-6736(99)02784-1; Bischoff SC, 2002, INT ARCH ALLERGY IMM, V127, P118, DOI 10.1159-000048181; Braddock M, 1999, INT J DERMATOL, V38, P808, DOI 10.1046-j.1365-4362.1999.00832.x; BREUING K, 1992, J SURG RES, V52, P50, DOI 10.1016-0022-4804(92)90278-8; Carrington LM, 2006, INVEST OPHTH VIS SCI, V47, P1886, DOI 10.1167-iovs.05-0635; CELLINI M, 2006, OPHTHAL RES, V4, P177; Chen T, 2006, LARYNGOSCOPE, V116, P514, DOI 10.1097-01.MLG.0000205590.62824.OA; *CISTR BIOT INC, INT 1BETA ACC HEAL S; CONSTANTINOU J, 1994, NEUROREPORT, V5, P2281, DOI 10.1097-00001756-199411000-00019; Cool SM, 2004, KNEE SURG SPORT TR A, V12, P490, DOI 10.1007-s00167-003-0444-x; COOMBS CJ, 1992, BURNS, V18, P179, DOI 10.1016-0305-4179(92)90067-5; Corral CJ, 1999, ARCH SURG-CHICAGO, V134, P200, DOI 10.1001-archsurg.134.2.200; Corseaux D, 2000, CIRCULATION, V101, P2000; Cowin AJ, 2001, EUR J DERMATOL, V11, P424; Cribbs RK, 1998, J BURN CARE REHABIL, V19, P95, DOI 10.1097-00004630-199803000-00002; Cruise BA, 2004, DEV BIOL, V271, P1, DOI 10.1016-j.ydbio.2004.04.003; D'Amico D, 1978, Chir Ital, V30, P586; Dasu MRK, 2003, BURNS, V29, P527, DOI 10.1016-S0305-4179(03)00154-2; Debus ES, 2000, ZBL CHIR, V125, P49; Deng Wei-nian, 2002, Fa Yi Xue Za Zhi, V18, P121; Diegelmann RF, 2004, FRONT BIOSCI, V9, P283, DOI 10.2741-1184; Dinarello CA, 1996, BLOOD, V87, P2095; DINARELLO CA, 1993, TRENDS PHARMACOL SCI, V14, P155, DOI 10.1016-0165-6147(93)90200-4; Dowdall JF, 2002, SURGERY, V132, P1, DOI 10.1067-msy.2002.121889; Egozi EI, 2003, WOUND REPAIR REGEN, V11, P46, DOI 10.1046-j.1524-475X.2003.11108.x; Faler Byron J, 2006, Perspect Vasc Surg Endovasc Ther, V18, P55, DOI 10.1177-153100350601800123; Filion RJ, 2004, ANN BIOMED ENG, V32, P645, DOI 10.1023-B:ABME.0000030231.88326.78; Fortunato SJ, 2003, PLACENTA, V24, P922, DOI 10.1016-S0143-4004(03)00160-7; Frank S, 1996, J BIOL CHEM, V271, P10188; Fujisawa K, 2003, J ORAL PATHOL MED, V32, P358, DOI 10.1034-j.1600-0714.2003.t01-1-00111.x; Funato N, 1999, J DENT RES, V78, P1511; GAILIT J, 1994, J INVEST DERMATOL, V103, P221, DOI 10.1111-1523-1747.ep12393176; Generini S, 2004, EXP CLIN ENDOCR DIAB, V112, P542, DOI 10.1055-s-2004-821313; Gillitzer R, 2001, J LEUKOCYTE BIOL, V69, P513; Goldman Robert, 2004, Adv Skin Wound Care, V17, P24, DOI 10.1097-00129334-200401000-00012; Graiani G, 2004, DIABETOLOGIA, V47, P1047, DOI 10.1007-s00125-004-1414-7; Graves DT, 2001, J IMMUNOL, V167, P5316; Grove G. L., 1999, SKIN RES TECHNOL, V5, P9, DOI 10.1111-j.1600-0846.1999.tb00197.x; Günes Hayrettin Varol, 2006, Int Surg, V91, P151; HEBDA PA, 1993, DERMATOL CLIN, V11, P685; Heissig B, 2005, J EXP MED, V202, P739, DOI 10.1081-jem.20050959; Huttunen M, 2002, ARCH DERMATOL RES, V294, P324, DOI 10.1007-s00403-002-0331-1; Huttunen M, 2001, EXP DERMATOL, V10, P184, DOI 10.1034-j.1600-0625.2001.010003184.x; Huttunen M, 2005, BRIT J DERMATOL, V152, P1149, DOI 10.1111-j.1365-2133.2005.06428.x; Iba Y, 2004, INT IMMUNOPHARMACOL, V4, P1873, DOI 10.1016-j.intimp.2004.08.009; Iwakura A, 2003, J THORAC CARDIOV SUR, V126, P1113, DOI 10.1016-S0022-5223(03)00025-4; Jeschke MG, 1999, GENE THER, V6, P1015, DOI 10.1038-sj.gt.3300923; Jurjus AR, 1998, J NEUROIMMUNOL, V90, P143, DOI 10.1016-S0165-5728(98)00097-6; Kanaan SA, 2000, PAIN, V85, P477, DOI 10.1016-S0304-3959(99)00297-3; Kapoun AM, 2006, MOL PHARMACOL, V70, P518, DOI 10.1124-mol.105.021600; Kawamoto K, 2004, PROG BRAIN RES, V146, P369; Knabl JS, 1999, BURNS, V25, P229, DOI 10.1016-S0305-4179(98)00172-7; Lambiase A, 2003, ARCH ITAL BIOL, V141, P141; Landi F, 2003, ANN INTERN MED, V139, P635; Li Zhi-qing, 2004, Di Yi Jun Yi Da Xue Xue Bao, V24, P1255; Mani H, 2004, SKIN PHARMACOL PHYSI, V17, P49, DOI 10.1159-000074063; Martin P, 2005, TRENDS CELL BIOL, V15, P599, DOI 10.1016-j.tcb.2005.09.002; Maurer M, 2003, EXP DERMATOL, V12, P886, DOI 10.1111-j.0906-6705.2003.0109a.x; Meghji S, 1996, ARCH ORAL BIOL, V41, P523, DOI 10.1016-0003-9969(96)00032-5; Mercado AM, 2002, J NEUROIMMUNOL, V129, P74, DOI 10.1016-S0165-5728(02)00174-1; Micera A, 2003, CYTOKINE GROWTH F R, V14, P369, DOI 10.1016-S1359-6101(03)00047-9; Micera A, 2005, CLIN EXP ALLERGY, V35, P650, DOI 10.1111-j.1365-2222.2005.02241.x; MICERA A, 2006, EXP EYE RES, V20; Moyer KE, 2004, WOUND REPAIR REGEN, V12, P269, DOI 10.1111-j.1067-1927.2004.012310.x; Muangman P, 2004, WOUND REPAIR REGEN, V12, P44, DOI 10.1111-j.1067-1927.2004.012110.x-1; Narayanan S, 2005, EXP EYE RES, V80, P175, DOI 10.1016-j.exer.2004.08.027; Niessen FB, 2004, J PATHOL, V202, P121, DOI 10.1002-path.1502; Nishikori Y, 1998, ARCH DERMATOL RES, V290, P553, DOI 10.1007-s004030050351; Nithya M, 2003, BBA-GEN SUBJECTS, V1620, P25, DOI 10.1016-S0304-4165(02)00501-9; Noli C, 2001, VET DERMATOL, V12, P303, DOI 10.1046-j.0959-4493.2001.00272.x; Obara K, 2005, WOUND REPAIR REGEN, V13, P390, DOI 10.1111-j.1067-1927.2005.130406.x; Oda Y, 2004, J ORAL MAXIL SURG, V62, P73, DOI 10.1016-j.joms.2003.05.007; Ono I, 2004, WOUND REPAIR REGEN, V12, P67, DOI 10.1111-j.1067-1927.2004.012113.x-1; Ornitz D. M., 2001, GENOME BIOL, V2; Plum SM, 2004, IMMUNOPHARM IMMUNOT, V26, P29, DOI 10.1081-IPH-120029942; Politis MJ, 1998, PLAST RECONSTR SURG, V102, P2404, DOI 10.1097-00006534-199812000-00020; Reno F, 2003, WOUND REPAIR REGEN, V11, P331, DOI 10.1046-j.1524-475X.2003.11504.x; Reyes A, 2001, ANN BURNS FIRE DISAS, V14, P183; Ribatti D, 1999, Angiogenesis, V3, P89, DOI 10.1023-A:1009049932252; SAFIEHGARABEDIAN B, 1995, BRIT J PHARMACOL, V115, P1265; Saliba MJ, 2001, BURNS, V27, P349, DOI 10.1016-S0305-4179(00)00130-3; Sasaki A, 2003, PLAST RECONSTR SURG, V111, P1446, DOI 10.1097-01.PRS.0000049451.38505.45; Schmid P, 1998, AM J PATHOL, V152, P485; Schultze-Mosgau S, 2004, BRIT J ORAL MAX SURG, V42, P112, DOI 10.1016-S0266-4356(03)00257-2; Shi CM, 2003, J RADIAT RES, V44, P223, DOI 10.1269-jrr.44.223; Takami Y, 2005, BIOCHEM BIOPH RES CO, V327, P212, DOI 10.1016-j.bbrc.2004.11.144; Tatefuji T, 2006, BIOL PHARM BULL, V29, P896, DOI 10.1248-bpb.29.896; Tonks AJ, 2003, CYTOKINE, V21, P242, DOI 10.1016-S1043-4666(03)00092-9; Trautmann A, 2000, J PATHOL, V190, P100, DOI 10.1002-(SICI)1096-9896(200001)190:1100::AID-PATH4963.0.CO;2-Q; Trengove NJ, 2000, WOUND REPAIR REGEN, V8, P13, DOI 10.1046-j.1524-475x.2000.00013.x; Venkataraman G, 1999, P NATL ACAD SCI USA, V96, P3658, DOI 10.1073-pnas.96.7.3658; Verrecchia F, 2002, J INVEST DERMATOL, V118, P211, DOI 10.1046-j.1523-1747.2002.01641.x; Werner S, 2003, PHYSIOL REV, V83, P835, DOI 10.1152-physrev.00031.2002; WUSTROW TPU, 1994, HEAD NECK-J SCI SPEC, V16, P88, DOI 10.1002-hed.2880160118; Xing Bang-rong, 2003, Zhonghua Shao Shang Za Zhi, V19, P340; Yalamanchi N, 2004, PLAST RECONSTR SURG, V113, P625, DOI 10.1097-01.PRS.0000101529.47062.34; Yoganathan S, 2003, LIPIDS, V38, P603, DOI 10.1007-s11745-003-1104-y; Yu HY, 2006, J PLAST RECONSTR AES, V59, P221, DOI 10.1016-j.bjps.2005.06.010; ZAMBRUNO G, 1995, J CELL BIOL, V129, P853, DOI 10.1083-jcb.129.3.853; Zarrinkalam KH, 2003, KIDNEY INT, V64, P331, DOI 10.1046-j.1523-1755.2003.00069.x; Zhang XM, 2004, J IMMUNOL, V173, P3514

Pharmacological modulation of wound healing in experimental burns

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