Journal article
Pharmacological therapies in post stroke recovery: recommendations for future clinical trials
Journal of neurology, Vol.261(8), pp.1461-1468
08/2014
DOI: 10.1007/s00415-013-7172-z
PMID: 24221642
Abstract
Stroke is a leading cause of serious long-term disability in adults and is the second leading cause of death worldwide. Early reperfusion and neuroprotection techniques have been the focus of much effort with the aim of very acute treatment of the stroke. Targeting different mechanisms, pharmacological therapies have the potential to reduce disability in a large fraction of patients who survive the acute stroke. The brain’s capacity to reorganize after stroke through plasticity mechanisms can be modulated by pharmacological agents. A number of therapeutic interventions are under study, including small molecules, growth factors, and monoclonal antibodies. Recently it has been shown that the SSRI fluoxetine improved motor deficit in patients with ischaemic stroke and hemiplegia which appeared to be independent of the presence of depression. In this context, it is of major importance to support innovative research in order to promote the emergence of new pharmacological treatments targeting neurological recovery after stroke, as opposed to acute de-occlusion and neuroprotection. This paper is the work of a group of 14 scientists with aim of (1) addressing key areas of the basic and clinical aspects of human brain plasticity after stroke and potential pharmacological targets for recovery, (2) asking questions about the most appropriate characteristics of clinical trials testing drugs in post stroke recovery and (3) proposing recommendations for future clinical trials.
Details
- Title: Subtitle
- Pharmacological therapies in post stroke recovery: recommendations for future clinical trials
- Creators
- F Chollet - Department of Neurology Hopital Purpan, Place Baylac Toulouse 31059 FranceS Cramer - Departments of Neurology and Anatomy and Neurobiology University of California Irvine Irvine USAC Stinear - Department of Medicine, Centre for Brain Research University of Auckland Auckland New ZealandL J Kappelle - Utrecht Stroke Centre, University Medical Centre Utrecht The NetherlandsJ C Baron - INSERM U894, Sorbonne Paris Cité Université Paris Descartes Paris FranceC Weiller - Department of Neurology, University Medical Center University of Freiburg Freiburg GermanyP Azouvi - Service de Médecine Physique et Réadaptation, AP-HP, Hôpital Raymond Poincaré Université de Versailles-Saint-Quentin Garches FranceM Hommel - University Hospital Grenoble Grenoble FranceU Sabatini - Radiology Department IRCCS Fondazione S. Lucia via Ardeatina 306 00179 Rome ItalyT Moulin - CHU de Besançon Besançon FranceJ Tardy - Clinique des Cèdres Cornebarrieu FranceM Valenti - Section of Clinical Epidemiology, Department of Applied Clinical Sciences and Biotechnology University of L’Aquila L’Aquila ItalyS Montgomery - Imperial College London London UKH Adams Jr - Department of Neurology University of Iowa Iowa USA
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, Vol.261(8), pp.1461-1468
- Publisher
- Springer Berlin Heidelberg; Berlin/Heidelberg
- DOI
- 10.1007/s00415-013-7172-z
- PMID
- 24221642
- ISSN
- 0340-5354
- eISSN
- 1432-1459
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020794502771
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