Journal article
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity
The European respiratory journal, Vol.45(1), pp.87-97
01/2015
DOI: 10.1183/09031936.00042414
PMCID: PMC4283933
PMID: 25359343
Abstract
S-Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S-nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients. We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in the Severe Asthma Research Program. We also analysed phenotype and genotype data taken from the program as a whole. Airway S-nitrosoglutathione reductase activity was increased in asthma patients (p=0.032). However, only a subpopulation was affected and this subpopulation was not defined by a "severe asthma" diagnosis. Subjects with increased activity were younger, had higher IgE and an earlier onset of symptoms. Consistent with a link between S-nitrosoglutathione biochemistry and atopy: 1) interleukin 13 increased S-nitrosoglutathione reductase expression and 2) subjects with an S-nitrosoglutathione reductase single nucleotide polymorphism previously associated with asthma had higher IgE than those without this single nucleotide polymorphism. Expression was higher in airway epithelium than in smooth muscle and was increased in regions of the asthmatic lung with decreased airflow. An early-onset, allergic phenotype characterises the asthma population with increased S-nitrosoglutathione reductase activity.
Details
- Title: Subtitle
- Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity
- Creators
- Nadzeya V Marozkina - Case Western Reserve UniversityXin-Qun Wang - University of VirginiaVitali Stsiapura - University of VirginiaAnne Fitzpatrick - Emory UniversitySilvia Carraro - University of PaduaGregory A Hawkins - Wake Forest UniversityEugene Bleecker - Wake Forest UniversityDeborah Meyers - Wake Forest UniversityNizar Jarjour - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–MadisonSally Wenzel - University of PittsburghWilliam Busse - University of Wisconsin–MadisonMario Castro - Washington University in St. LouisReynold A Panettieri Jr - University of PennsylvaniaWendy Moore - Wake Forest UniversityStephen J Lewis - Case Western Reserve UniversityLisa A Palmer - University of VirginiaTalissa Altes - University of VirginiaEduard E de Lange - University of VirginiaSerpil Erzurum - Cleveland ClinicW Gerald Teague - University of VirginiaBenjamin Gaston - Case Western Reserve University
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.45(1), pp.87-97
- DOI
- 10.1183/09031936.00042414
- PMID
- 25359343
- PMCID
- PMC4283933
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- R01 HL097796 / NHLBI NIH HHS P01 HL103453 / NHLBI NIH HHS P01 HL114471 / NHLBI NIH HHS U10 HL109250 / NHLBI NIH HHS 5P01HL101871-02 / NHLBI NIH HHS P01 HL101871 / NHLBI NIH HHS R01 HL069167 / NHLBI NIH HHS R01 HL66479 / NHLBI NIH HHS 5U10HL109250-02 / NHLBI NIH HHS R01 HL059337 / NHLBI NIH HHS P30 ES013508 / NIEHS NIH HHS UL1 TR000427 / NCATS NIH HHS R24 HL123767 / NHLBI NIH HHS M01 RR000847 / NCRR NIH HHS 5R01-HL059337-12 / NHLBI NIH HHS R01 HL066479 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274959302771
Metrics
25 Record Views