Journal article
Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell
Journal of virology, Vol.95(12), e00165-21
04/07/2021
DOI: 10.1128/JVI.00165-21
PMID: 33827945
Abstract
Immune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain inconclusive. In this study, we identified a novel mouse spleen NK cell subset expressing NKp46 and NKG2A induced by intranasal influenza virus infection. These memory NK cells specifically recognize
-linked glycosylation sites on influenza hemagglutinin (HA) protein. Different from memory-like NK cells reported previously, these NKp46
NKG2A
memory NK cells exhibited HA-specific silence of cytotoxicity but increase of IFN-γ response against influenza virus-infected cells, which could be reversed by Pifithrin-μ, a p53-HSP70 signaling inhibitor. During recall responses, splenic NKp46
NKG2A
NK cells were recruited to infected lung and modulated viral clearance of virus and CD8
T cell distribution, resulting in improved clinical outcomes. This long-lived NK memory bridges innate and adaptive immune memory response and promotes the homeostasis of local environment during recall response.
In this study, we demonstrate a novel HA-specific NKp46
NKG2A
NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased IFN-γ on re-encountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.
Details
- Title: Subtitle
- Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell
- Creators
- Jian Zheng - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USALiyan Wen - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongHui-Ling Yen - School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongMing Liu - State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaYinping Liu - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongOoiean Teng - School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongWing-Fung Wu - School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongKe Ni - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongKowk-Tai Lam - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongChunyu Huang - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongJiashuang Yang - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongYu-Lung Lau - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong KongStanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USAMalik Peiris - School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong wwtu@hku.hk malik@hku.hk jian-zheng-1@uiowa.eduWenwei Tu - Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong wwtu@hku.hk malik@hku.hk jian-zheng-1@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.95(12), e00165-21
- DOI
- 10.1128/JVI.00165-21
- PMID
- 33827945
- NLM abbreviation
- J Virol
- eISSN
- 1098-5514
- Publisher
- United States
- Grant note
- DOI: 10.13039/501100002920, name: Research Grants Council, University Grants Committee, award: 17121214, 17115015, 17126317, 17122519, T11-705/14N; DOI: 10.13039/501100002920, name: Research Grants Council, University Grants Committee, award: T11-705/14N; DOI: 10.13039/501100002920, name: Research Grants Council, University Grants Committee, award: T11-705/14N
- Language
- English
- Date published
- 04/07/2021
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984071962602771
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