Journal article
Phenotypic drug resistance patterns in subtype a HIV-1 clones with nonnucleoside reverse transcriptase resistance mutations
AIDS research and human retroviruses, Vol.22(3), pp.289-293
2006
DOI: 10.1089/aid.2006.22.289
PMID: 16545016
Abstract
We analyzed the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) susceptibility of 29 subtype A HIV-1 clones isolated from 10 Ugandan women after single-dose nevirapine (NVP) administration. Six clones had no NNRTI resistance-associated mutations ("wild type"), eight had K103N, nine had Y181C, five had G190A, and one had Y181S. Three clones displayed unexpected phenotypic drug susceptibility/resistance based on their RT genotypes. One wild-type clone had reduced susceptibility to NVP, delavirdine (DLV), and efavirenz (EFV), one clone with K103N was susceptible to all three NNRTIs, and one clone with G190A had extreme hypersusceptibility to DLV. Three unusual HIV-1 RT amino acid substitutions may have contributed to the unexpected phenotypes of the clones: I31T, N136S, and N265D. These polymorphisms were rarely detected among 47,900 HIV-1 genotypes from clinical samples of predominantly United States origin. Further studies are needed to define the genetic correlates of antiretroviral drug resistance in nonsubtype B HIV-1.
Details
- Title: Subtitle
- Phenotypic drug resistance patterns in subtype a HIV-1 clones with nonnucleoside reverse transcriptase resistance mutations
- Creators
- Susan H ESHLEMAN - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesDana JONES - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesJustin GALOVICH - Monogram Biosciences, South San Francisco, California 94080, United StatesEllen E PAXINOS - Monogram Biosciences, South San Francisco, California 94080, United StatesChristos J PETROPOULOS - Monogram Biosciences, South San Francisco, California 94080, United StatesJ. Brooks JACKSON - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesNeil PARKIN - Monogram Biosciences, South San Francisco, California 94080, United States
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.22(3), pp.289-293
- Publisher
- Liebert; Larchmont, NY
- DOI
- 10.1089/aid.2006.22.289
- PMID
- 16545016
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 2006
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047706702771
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