Journal article
Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)
Journal of the peripheral nervous system, Vol.19(2), pp.77-87
06/01/2014
DOI: 10.1111/jns5.12072
PMCID: PMC4303044
PMID: 24934510
Abstract
NIDDK, JDRF, and the Diabetic Neuropathy Study Group of EASD sponsored a meeting to explore the current status of animal models of diabetic peripheral neuropathy. The goal of the workshop was to develop a set of consensus criteria for the phenotyping of rodent models of diabetic neuropathy. The discussion was divided into five areas: (1) status of commonly used rodent models of diabetes, (2) nerve structure, (3) electrophysiological assessments of nerve function, (4) behavioral assessments of nerve function, and (5) the role of biomarkers in disease phenotyping. Participants discussed the current understanding of each area, gold standards (if applicable) for assessments of function, improvements of existing techniques, and utility of known and exploratory biomarkers. The research opportunities in each area were outlined, providing a possible roadmap for future studies. The meeting concluded with a discussion on the merits and limitations of a unified approach to phenotyping rodent models of diabetic neuropathy and a consensus formed on the definition of the minimum criteria required for establishing the presence of the disease. A neuropathy phenotype in rodents was defined as the presence of statistically different values between diabetic and control animals in 2 of 3 assessments (nocifensive behavior, nerve conduction velocities, or nerve structure). The participants propose that this framework would allow different research groups to compare and share data, with an emphasis on data targeted toward the therapeutic efficacy of drug interventions.
Details
- Title: Subtitle
- Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)
- Creators
- G. J. Biessels - Diagnostics for the Real World (United Kingdom)V. Bril - Diagnostics for the Real World (United Kingdom)N. A. Calcutt - Diagnostics for the Real World (United Kingdom)N. E. Cameron - Diagnostics for the Real World (United Kingdom)M. A. Cotter - Diagnostics for the Real World (United Kingdom)R. Dobrowsky - Diagnostics for the Real World (United Kingdom)E. L. Feldman - Diagnostics for the Real World (United Kingdom)P. Fernyhough - Diagnostics for the Real World (United Kingdom)J. Jakobsen - Diagnostics for the Real World (United Kingdom)R. A. Malik - Diagnostics for the Real World (United Kingdom)A. P. Mizisin - Diagnostics for the Real World (United Kingdom)P. J. Oates - Diagnostics for the Real World (United Kingdom)I. G. Obrosova - Diagnostics for the Real World (United Kingdom)R. Pop-Busui - Diagnostics for the Real World (United Kingdom)J. W. Russell - Diagnostics for the Real World (United Kingdom)A. A. Sima - Diagnostics for the Real World (United Kingdom)M. J. Stevens - Diagnostics for the Real World (United Kingdom)R. E. Schmidt - Diagnostics for the Real World (United Kingdom)S. Tesfaye - Diagnostics for the Real World (United Kingdom)A. Veves - Diagnostics for the Real World (United Kingdom)A. I. Vinik - Diagnostics for the Real World (United Kingdom)D. E. Wright - Diagnostics for the Real World (United Kingdom)S. Yagihashi - Diagnostics for the Real World (United Kingdom)M. A. Yorek - Diagnostics for the Real World (United Kingdom)D. Ziegler - Diagnostics for the Real World (United Kingdom)D. W. Zochodne - Diagnostics for the Real World (United Kingdom)
- Resource Type
- Journal article
- Publication Details
- Journal of the peripheral nervous system, Vol.19(2), pp.77-87
- DOI
- 10.1111/jns5.12072
- PMID
- 24934510
- PMCID
- PMC4303044
- NLM abbreviation
- J Peripher Nerv Syst
- ISSN
- 1085-9489
- eISSN
- 1529-8027
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- R01NS054847 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) I01 RX001030 / RRD VA R01 NS043314; R01 NS054847 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) I01RX001030 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359890802771
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