Journal article
Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study
Journal of rheumatology, Vol.48(1), pp.123-128
01/01/2021
DOI: 10.3899/JRHEUM.200054
PMCID: PMC8039838
PMID: 32358162
Abstract
To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis(OA) progression using a metabolomics approach.
Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized into 2 groups based on the presence of baseline radiographic OA. Subjects in group 1 had unilateral knee OA and subjects in group 2 had bilateral knee OA. Progression was defined as a half-grade or greater worsening in joint space width at 30-month follow-up. For group 1, a participant progressed when their OA knee showed radiographic progression and the contralateral knee developed OA; for group 2, a participant progressed when both knees with OA showed radiographic progression. Metabolomic profiling was performed on plasma samples collected at baseline and logistic regression was performed to test the association between each metabolite and knee OA progression after adjustment for age, sex, BMI, and clinic site. Significance was defined as
≤ 0.0003 in the combined analysis.
There were 234 progressors (57 in group 1 and 177 in group 2) and 322 nonprogressors (206 in group 1 and 116 in group 2) included in the analyses. Among 157 metabolites studied, we found that odds of progression were 1.46 times higher per SD increase of phenylalanine level (95% CI 1.20-1.77,
= 0.0001) in the combined analysis. Sex-specific analysis showed that an association was seen in women (
= 0.0002) but not in men.
Our data suggest that phenylalanine might be a novel plasma marker for higher risk of bilateral radiographic knee OA progression in women.
Details
- Title: Subtitle
- Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study
- Creators
- Guangju Zhai - G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada; guangju.zhai@med.mun.caXianbang Sun - X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USAEdward W Randell - E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, CanadaMing Liu - G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, CanadaNa Wang - N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USAIrina Tolstykh - I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USAProton Rahman - P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, CanadaJames Torner - J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USACora E Lewis - C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USAMichael C Nevitt - I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USAAli Guermazi - A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USAFrank Roemer - A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USADavid T Felson - D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.48(1), pp.123-128
- DOI
- 10.3899/JRHEUM.200054
- PMID
- 32358162
- PMCID
- PMC8039838
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS FRN153298 / CIHR U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984214834902771
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