Journal article
Phenytoin-Induced Agranulocytosis: A Nonimmunologic Idiosyncratic Reaction?
Acta haematologica, Vol.86(4), pp.212-213
1991
DOI: 10.1159/000204838
PMID: 1805490
Abstract
Agranulocytosis is a rare side effect of phenytoin treatment. We describe the case of an elderly man who developed agranulocytosis 2 weeks following initiation of phenytoin treatment, on no cytotoxic drugs or any other medications except decadron. The white blood cell count was 300/mm3 with absent granulocytes. The liver enzymes were also noted to be newly elevated. Complete workup showed no evidence of infection. The patient was managed as a case of neutropenic fever and phenytoin was discontinued. A bone marrow biopsy showed absent granulocyte precursors after myelocytes, and an antigranulocyte antibody titer was negative, which suggests a direct toxic effect rather than an immunologic phenomenon. Both agranulocytosis and hepatitis were readily reversible on phenytoin cessation.
Details
- Title: Subtitle
- Phenytoin-Induced Agranulocytosis: A Nonimmunologic Idiosyncratic Reaction?
- Creators
- Melhem J.A SharafuddinRobert G SpanheimerGrant L McClune
- Resource Type
- Journal article
- Publication Details
- Acta haematologica, Vol.86(4), pp.212-213
- Publisher
- Basel, Switzerland
- DOI
- 10.1159/000204838
- PMID
- 1805490
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- Number of pages
- 2
- Language
- English
- Date published
- 1991
- Academic Unit
- Radiology; Surgery
- Record Identifier
- 9984051540602771
Metrics
8 Record Views