Journal article
Phobic anxiety in late-life in relationship to cognition and 5HTTLPR polymorphism
Psychiatric genetics, Vol.15(4), pp.305-306
12/2005
DOI: 10.1097/00041444-200512000-00016
PMID: 16314764
Abstract
Anxiety in late-life may functionally impair the older adult. In this study the polymorphic region 5HTTLPR of the SLC6A4 gene was examined in relation to phobic anxiety and cognitive function. Sixty-four community-dwelling older adults were genotyped for the 5HTTLPR polymorphism to examine whether late-life phobias are associated with the short (s) allele and whether cognitive impairment may precipitate phobic behaviors in association with the s allele. Our findings suggested that phobic anxiety symptoms are significantly related to lower cognitive function. However, in this sample we did not detect a significant association between phobic anxiety and the 5HTTLPR genotype. The interaction between age-related changes in cognition and anxiety remain an important area for future studies.
Details
- Title: Subtitle
- Phobic anxiety in late-life in relationship to cognition and 5HTTLPR polymorphism
- Creators
- Susan K SchultzDavid J MoserJeffrey R BishopVicki L Ellingrod
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.15(4), pp.305-306
- Publisher
- England
- DOI
- 10.1097/00041444-200512000-00016
- PMID
- 16314764
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Grant note
- 5K08MH064158-04 / NIMH NIH HHS 5K23AG020649-03 / NIA NIH HHS
- Language
- English
- Date published
- 12/2005
- Academic Unit
- Psychiatry; Medicine Administration; Internal Medicine
- Record Identifier
- 9984003903902771
Metrics
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