Phomadecalins A-D and phomapentenone A: new bioactive metabolites from Phoma sp. NRRL 25697, a fungal colonist of Hypoxylon stromata

Yongsheng Che; James B Gloer; Donald T Wicklow

doi:10.1021/np010519o

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Phomadecalins A-D and phomapentenone A: new bioactive metabolites from Phoma sp. NRRL 25697, a fungal colonist of Hypoxylon stromata

Journal article

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Phomadecalins A-D and phomapentenone A: new bioactive metabolites from Phoma sp. NRRL 25697, a fungal colonist of Hypoxylon stromata

Yongsheng Che, James B Gloer and Donald T Wicklow

Journal of natural products (Washington, D.C.), Vol.65(3), pp.399-402

03/2002

DOI: 10.1021/np010519o

PMID: 11908990

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Abstract

Five new natural products, phomadecalins A-D (1-4) and phomapentenone A (5), have been obtained from cultures of Phoma sp. (NRRL 25697), a fungal colonist isolated from the stromata of Hypoxylon sp. The structures of these compounds were elucidated through a series of 1D and 2D NMR experiments. Compounds 1-4 display activity against Gram-positive bacteria.

Antifungal Agents - chemistry

Antifungal Agents - isolation & purification

Antifungal Agents - pharmacology

Aspergillus flavus - drug effects

Bacillus subtilis - drug effects

Candida albicans - drug effects

Chromatography, High Pressure Liquid

Crystallography, X-Ray

Cyclopentanes - chemistry

Cyclopentanes - isolation & purification

Cyclopentanes - pharmacology

Fungi - chemistry

Fusarium - drug effects

Molecular Structure

Nuclear Magnetic Resonance, Biomolecular

Staphylococcus - drug effects

Details

Title: Subtitle: Phomadecalins A-D and phomapentenone A: new bioactive metabolites from Phoma sp. NRRL 25697, a fungal colonist of Hypoxylon stromata
Creators: Yongsheng Che - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
James B Gloer
Donald T Wicklow
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.65(3), pp.399-402
DOI: 10.1021/np010519o
PMID: 11908990
ISSN: 0163-3864
eISSN: 1520-6025
Language: English
Date published: 03/2002
Academic Unit: Chemistry
Record Identifier: 9984216568302771

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