Phosphatidylserine receptors: enhancers of enveloped virus entry and infection

Sven Moller-Tank; Wendy Maury

doi:10.1016/j.virol.2014.09.009

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Phosphatidylserine receptors: enhancers of enveloped virus entry and infection

Journal article

Open access

Peer reviewed

Phosphatidylserine receptors: enhancers of enveloped virus entry and infection

Sven Moller-Tank and Wendy Maury

Virology (New York, N.Y.), Vol.468-470, pp.565-580

11/2014

DOI: 10.1016/j.virol.2014.09.009

PMCID: PMC4252826

PMID: 25277499

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Abstract

A variety of both RNA and DNA viruses envelop their capsids in a lipid bilayer. One of the more recently appreciated benefits this envelope is incorporation of phosphatidylserine (PtdSer). Surface exposure of PtdSer disguises viruses as apoptotic bodies; tricking cells into engulfing virions. This mechanism is termed apoptotic mimicry. Several PtdSer receptors have been identified to enhance virus entry and we have termed this group of proteins PtdSer-mediated virus entry enhancing receptors or PVEERs. These receptors enhance entry of a range of enveloped viruses. Internalization of virions by PVEERs provides a broad mechanism of entry with little investment by the virus itself. PVEERs may allow some viruses to attach to cells, thereby making viral glycoprotein/cellular receptor interactions more probable. Alternatively, other viruses may rely entirely on PVEERs for internalization into endosomes. This review provides an overview of PtdSer receptors that serve as PVEERs and the biology behind virion/PVEER interaction.

Receptors, Virus - metabolism

Humans

Gene Expression Regulation

RNA Viruses - physiology

Receptors, Cell Surface - metabolism

Receptors, Virus - genetics

Virus Internalization

Baculoviridae - physiology

Receptors, Cell Surface - genetics

Details

Title: Subtitle: Phosphatidylserine receptors: enhancers of enveloped virus entry and infection
Creators: Sven Moller-Tank - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Wendy Maury - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: wendy-maury@uiowa.edu
Resource Type: Journal article
Publication Details: Virology (New York, N.Y.), Vol.468-470, pp.565-580
DOI: 10.1016/j.virol.2014.09.009
PMID: 25277499
PMCID: PMC4252826
NLM abbreviation: Virology
ISSN: 0042-6822
eISSN: 1096-0341
Grant note: R01 AI077519 / NIAID NIH HHS
Language: English
Date published: 11/2014
Academic Unit: Microbiology and Immunology
Record Identifier: 9984083870202771

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