Journal article
Phosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications
Neuroscience, Vol.129(1), pp.101-107
2004
DOI: 10.1016/j.neuroscience.2004.07.038
PMID: 15489033
Abstract
OverviewAll current antipsychotic medications work by binding to Gi-coupled dopamine (DA) D2 receptors. Such medications are thought to affect cellular function primarily by decreasing DA-mediated regulation of intracellular cyclic adenosine monophosphate (cAMP).However, several studies indicate that cAMP signal transduction abnormalities in schizophrenia may not be limited to D2-containing cells. The current study examines the potential of using non-receptor-based agents that modify intracellular signal transduction as potential antipsychotic medications.
MethodsThe indirect DA agonist amphetamine has been used to model the auditory sensory processing deficits in schizophrenia. Such pharmacologically induced abnormalities are reversed by current antipsychotic treatments. This study examines the ability of the phosphodiesterase-4 inhibitor, rolipram, to reverse amphetamine-induced abnormalities in auditory-evoked potentials that are characteristic of schizophrenia.
ResultsRolipram reverses amphetamine-induced reductions in auditory-evoked potentials.
ConclusionThis finding could lead to novel approaches to receptor-independent treatments for schizophrenia.
Details
- Title: Subtitle
- Phosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications
- Creators
- C.R Maxwell - Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USAS.J Kanes - Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USAT Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA, USAS.J Siegel - Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
- Resource Type
- Journal article
- Publication Details
- Neuroscience, Vol.129(1), pp.101-107
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.neuroscience.2004.07.038
- PMID
- 15489033
- ISSN
- 0306-4522
- eISSN
- 1873-7544
- Language
- English
- Date published
- 2004
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065828602771
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