Photo-Crosslinked Silk Fibroin for 3D Printing

Xuan Mu; Jugal Kishore Sahoo; Peggy Cebe; David L. Kaplan

doi:10.3390/polym12122936

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Photo-Crosslinked Silk Fibroin for 3D Printing

Journal article

Open access

Peer reviewed

Photo-Crosslinked Silk Fibroin for 3D Printing

Xuan Mu, Jugal Kishore Sahoo, Peggy Cebe and David L. Kaplan

Polymers, Vol.12(12), pp.1-18

12/01/2020

DOI: 10.3390/polym12122936

PMCID: PMC7763742

PMID: 33316890

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https://doi.org/10.3390/polym12122936View

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Abstract

Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future.

Physical Sciences

Polymer Science

Science & Technology

Details

Title: Subtitle: Photo-Crosslinked Silk Fibroin for 3D Printing
Creators: Xuan Mu - Tufts University
Jugal Kishore Sahoo - Tufts University
Peggy Cebe - Tufts University
David L. Kaplan - Tufts University
Resource Type: Journal article
Publication Details: Polymers, Vol.12(12), pp.1-18
DOI: 10.3390/polym12122936
PMID: 33316890
PMCID: PMC7763742
NLM abbreviation: Polymers (Basel)
ISSN: 2073-4360
eISSN: 2073-4360
Publisher: Mdpi
Number of pages: 18
Grant note: P41EB027062; R01EB021264; R01NS092847; U01EB014976 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA DMR-1608125 / NSF; National Science Foundation (NSF) FA9550-17-1-0333 / AFOSR; United States Department of Defense; Air Force Office of Scientific Research (AFOSR)
Language: English
Date published: 12/01/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984276454802771

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