Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas

Jeffrey D Rytlewski; Nicholas Scalora; Keith Garcia; Munir Tanas; Fatima Toor; Benjamin Miller; Bryan Allen; Mohammed Milhem; Varun Monga

doi:10.3390/cancers13040675

Back

Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas

Journal article

Open access

Peer reviewed

Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas

Jeffrey D Rytlewski, Nicholas Scalora, Keith Garcia, Munir Tanas, Fatima Toor, Benjamin Miller, Bryan Allen, Mohammed Milhem and Varun Monga

Cancers, Vol.13(4), pp.1-11

02/08/2021

DOI: 10.3390/cancers13040675

PMCID: PMC7915813

PMID: 33567506

Files and links (1)

url

https://doi.org/10.3390/cancers13040675View

Published (Version of record) Open Access

Abstract

Sarcoma is a widely varied and devastating oncological subtype, with overall five-year survival of 65% that drops to 16% with the presence of metastatic disease at diagnosis. Standard of care for localized sarcomas is predicated on local control with wide-local resection and radiation therapy, or, less commonly, chemotherapy, depending on tumor subtype. Verteporfin has the potential to be incorporated into this standard of care due to its unique molecular properties: inhibition of the upregulated Hippo pathway that frequently drives soft tissue sarcoma and photodynamic therapy-mediated necrosis due to oxidative damage. The initial anti-proliferative effect of verteporfin is mediated via binding and dissociation of YAP/TEAD proteins from the nucleus, ultimately leading to decreased cell proliferation as demonstrated in multiple in vitro studies. This effect has the potential to be compounded with use of photodynamic therapy to directly induce cellular necrosis with use of a clinical laser. Photodynamic therapy has been incorporated into multiple malignancies and has the potential to be incorporated into sarcoma treatment.

Hippo pathway

soft tissue sarcoma

YAP/TAZ

photodynamic therapy

verteporfin

Details

Title: Subtitle: Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas
Creators: Jeffrey D Rytlewski - University of Iowa
Nicholas Scalora - University of Iowa
Keith Garcia - University of Iowa
Munir Tanas - University of Iowa
Fatima Toor - University of Iowa
Benjamin Miller - University of Iowa
Bryan Allen - University of Iowa
Mohammed Milhem - University of Iowa
Varun Monga - University of Iowa
Resource Type: Journal article
Publication Details: Cancers, Vol.13(4), pp.1-11
DOI: 10.3390/cancers13040675
PMID: 33567506
PMCID: PMC7915813
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Grant note: 3P30CA086862-14S1 / NCI NIH HHS
Language: English
Date published: 02/08/2021
Academic Unit: Electrical and Computer Engineering; Iowa Technology Institute; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Orthopedics and Rehabilitation; Physics and Astronomy; Radiation Oncology; Holden Comprehensive Cancer Center; Internal Medicine
Record Identifier: 9984186395902771

Metrics

12 Record Views

7 Times Cited - Web of Science