Journal article
Photoreceptor outer segment as a sink for membrane proteins: hypothesis and implications in retinal ciliopathies
Human molecular genetics, Vol.26(R1), pp.R75-R82
08/01/2017
DOI: 10.1093/hmg/ddx163
PMCID: PMC5886464
PMID: 28453661
Abstract
The photoreceptor outer segment (OS) is a unique modification of the primary cilium, specialized for light perception. Being homologous organelles, the primary cilium and the OS share common building blocks and molecular machinery to construct and maintain them. The OS, however, has several unique structural features that are not seen in primary cilia. Although these unique features of the OS have been well documented, their implications in protein localization have been under-appreciated. In this review, we compare the structural properties of the primary cilium and the OS, and propose a hypothesis that the OS can act as a sink for membrane proteins. We further discuss the implications of this hypothesis in polarized protein localization in photoreceptors and mechanisms of photoreceptor degeneration in retinal ciliopathies.
Details
- Title: Subtitle
- Photoreceptor outer segment as a sink for membrane proteins: hypothesis and implications in retinal ciliopathies
- Creators
- Seongjin Seo - University of IowaPoppy Datta - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Human molecular genetics, Vol.26(R1), pp.R75-R82
- Publisher
- England
- DOI
- 10.1093/hmg/ddx163
- PMID
- 28453661
- PMCID
- PMC5886464
- ISSN
- 1460-2083
- eISSN
- 1460-2083
- Grant note
- R01 EY022616 / NEI NIH HHS
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979991802771
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