Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family

H S Stadler; J C Murray; N J Leysens; P J Goodfellow; M Solursh

doi:10.1007/BF00355637

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Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family

Journal article

Peer reviewed

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family

H S Stadler, J C Murray, N J Leysens, P J Goodfellow and M Solursh

Mammalian genome, Vol.6(6), pp.383-388

06/1995

DOI: 10.1007/BF00355637

PMID: 7647458

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Abstract

Homeobox genes represent a class of transcription factors that play key roles in the regulation of embryogenesis and development. Here we report the identification of a homeobox-containing gene family that is highly conserved at both the nucleotide and amino acid levels in a diverse number of species. These species encompass both vertebrate and invertebrate phylogenies, ranging from Homo sapiens to Drosophila melanogaster. In humans, at least two homeobox sequences from this family were identified representing a previously reported member of this family as well as a novel homeobox sequence that we physically mapped to the 10q25.2-q26.3 region of human Chromosome (Chr) 10. Multiple members of this family were also detected in three additional vertebrate species including Equus caballus (horse), Gallus gallus (Chicken), and Mus musculus (mouse), whereas only single members were detected in Tripneustes gratilla (sea urchin), Petromyzon marinus (lamprey), Salmo salar (salmon), Ovis aries (sheep), and D. melanogaster (fruit fly).

Amino Acid Sequence

Multigene Family

Animals

Base Sequence

DNA

Humans

Conserved Sequence

Molecular Sequence Data

Chromosome Mapping

Phylogeny

Chromosomes, Human, Pair 10

Genes, Homeobox

Details

Title: Subtitle: Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family
Creators: H S Stadler - University of Iowa, Department of Biological Sciences, Iowa City 52242, USA
J C Murray
N J Leysens
P J Goodfellow
M Solursh
Resource Type: Journal article
Publication Details: Mammalian genome, Vol.6(6), pp.383-388
DOI: 10.1007/BF00355637
PMID: 7647458
NLM abbreviation: Mamm Genome
ISSN: 0938-8990
eISSN: 1432-1777
Publisher: United States
Grant note: HG00355 / NHGRI NIH HHS HL07121 / NHLBI NIH HHS DE09170 / NIDCR NIH HHS
Language: English
Date published: 06/1995
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025408002771

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