Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans

James R Johnson; Michael A Kuskowski; Krista Owens; Abby Gajewski; Patricia L Winokur

doi:10.1086/377455

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Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans

Journal article

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Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans

James R Johnson, Michael A Kuskowski, Krista Owens, Abby Gajewski and Patricia L Winokur

The Journal of infectious diseases, Vol.188(5), pp.759-768

09/01/2003

DOI: 10.1086/377455

PMID: 12934193

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Abstract

In Escherichia coli infection, the implications of fluoroquinolone (FQ) and extended-spectrum cephalosporin plus cephamycin (AmpC) resistance for phylogenetic origin and virulence potential are undefined, as is the influence of ecological context on these associations. Accordingly, 106 E. coli isolates exhibiting FQ and/or AmpC resistance and 98 susceptible isolates were compared with regard to phylogenetic background and virulence profiles, stratified by host group (104 predominantly extraintestinal human isolates and 100 predominantly intestinal cattle and swine isolates). Although resistant isolates exhibited significant shifts in phylogenetic distribution and virulence profiles, human and animal isolates exhibited different phylogenetic shifts, and only among human isolates did resistance predict reduced virulence. Evidence for similar strains being resistant versus susceptible was scant. The O15:K52:H1 clonal group and the closely related "clonal group A" featured prominently among resistant and susceptible human isolates, respectively. Thus, in E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion.

Fluoroquinolones

Anti-Infective Agents - pharmacology

Cephalosporin Resistance

Escherichia coli - drug effects

Humans

Drug Resistance, Bacterial

Escherichia coli Infections - microbiology

Genotype

Phylogeny

Bacterial Proteins

Microbial Sensitivity Tests

Animals

Cephamycins - pharmacology

beta-Lactamases - genetics

Virulence - genetics

Cattle

Escherichia coli - genetics

Swine

Escherichia coli - pathogenicity

Random Amplified Polymorphic DNA Technique

Cephalosporins - pharmacology

Serotyping

Escherichia coli - classification

Details

Title: Subtitle: Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and humans
Creators: James R Johnson - Medical Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. johns007@umn.edu
Michael A Kuskowski
Krista Owens
Abby Gajewski
Patricia L Winokur
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.188(5), pp.759-768
DOI: 10.1086/377455
PMID: 12934193
ISSN: 0022-1899
eISSN: 1537-6613
Grant note: I01 CX000920 / CSRD VA DK-47504 / NIDDK NIH HHS
Language: English
Date published: 09/01/2003
Academic Unit: Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9984094630502771

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