Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study

Cassandra N Spracklen; Kelli K Ryckman; Elizabeth W Triche; Audrey F Saftlas

doi:10.1007/s10995-016-1919-y

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Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study

Journal article

Peer reviewed

Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study

Cassandra N Spracklen, Kelli K Ryckman, Elizabeth W Triche and Audrey F Saftlas

Maternal and child health journal, Vol.20(6), pp.1193-1202

06/2016

DOI: 10.1007/s10995-016-1919-y

PMCID: PMC5538351

PMID: 26910608

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http://doi.org/10.1007/s10995-016-1919-yView

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Abstract

Physical activity (PA) is hypothesized to reduce the risk of preeclampsia, but few epidemiologic studies have simultaneously evaluated leisure time PA (LTPA), sedentary activity, occupational activity, and non-occupational, non-leisure time PA. Thus, we assessed the independent and combined effects of these different types of PA during pregnancy on preeclampsia and gestational hypertension risk. Preeclamptic (n = 258), gestational hypertensive (n = 233), and normotensive (n = 182) women identified from Iowa live birth records (2002-2005) were participants in Study of Pregnancy Hypertension in Iowa. Disease status was verified by medical chart review. All PA exposures were self-reported. Multinomial logistic regression was used to test for associations between various PA types and risk for preeclampsia or gestational hypertension. After adjusting for prepregnancy BMI, increasing levels of LTPA were associated with a reduced risk of preeclampsia (trend, p = 0.02). Additionally, increasing amount of time spent active each day was associated with decreasing risks for preeclampsia (adjusted, trend; p = 0.03). Increasing amount of time spent sitting per day was associated with an increasing risk of preeclampsia (adjusted, trend; p = 0.10). Women whose activity averaged >8.25 h per day were at a significantly reduced risk of preeclampsia relative to women active <4.2 h per day (adjusted OR 0.58, 95 % CI 0.36, 0.95). Most analyses evaluating the risk of gestational hypertension yielded null results or results that trended in the direction opposite of the preeclampsia results. Consistent with previous studies, these data suggest increasing PA during pregnancy may reduce preeclampsia risk while increasing levels of sedentary activity may increase disease risk.

Leisure Activities

Pre-Eclampsia - epidemiology

Epidemiologic Studies

Humans

Risk Factors

Logistic Models

Pre-Eclampsia - etiology

Case-Control Studies

Pregnancy

Young Adult

Exercise

Employment

Adolescent

Hypertension, Pregnancy-Induced - epidemiology

Adult

Female

Iowa - epidemiology

Hypertension, Pregnancy-Induced - etiology

Details

Title: Subtitle: Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study
Creators: Cassandra N Spracklen - Department of Genetics, University of North Carolina-Chapel Hill, 5100 Genetic Medicine Building, CB# 7264, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA
Kelli K Ryckman - Department of Epidemiology, University of Iowa College of Public Health, 145 South Riverside Drive, S414 CPHB, Iowa City, IA, 52242, USA
Elizabeth W Triche - Department of Epidemiology, Brown University, Providence, RI, USA
Audrey F Saftlas - Department of Epidemiology, University of Iowa College of Public Health, 145 South Riverside Drive, S414 CPHB, Iowa City, IA, 52242, USA. audrey-saftlas@uiowa.edu
Resource Type: Journal article
Publication Details: Maternal and child health journal, Vol.20(6), pp.1193-1202
DOI: 10.1007/s10995-016-1919-y
PMID: 26910608
PMCID: PMC5538351
NLM abbreviation: Matern Child Health J
ISSN: 1573-6628
eISSN: 1573-6628
Publisher: United States
Grant note: R01 HD039753 / NICHD NIH HHS
Language: English
Date published: 06/2016
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983995012702771

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