Journal article
Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults
PloS one, Vol.10(8), pp.e0134819-e0134819
2015
DOI: 10.1371/journal.pone.0134819
PMCID: PMC4526228
PMID: 26244873
Abstract
Higher cardiorespiratory fitness (CRF) and physical activity (PA) in old age are associated with greater brain structural and functional integrity, and higher cognitive functioning. However, it is not known how different aspects of lifestyle such as sedentariness, light PA (LI-PA), or moderate-to-vigorous physical activity (MV-PA) relate to neural activity in aging. In addition, it is not known whether the effects of PA on brain function differ or overlap with those of CRF. Here, we objectively measured CRF as oxygen consumption during a maximal exercise test and measured PA with an accelerometer worn for 7 days in 100 healthy but low active older adults (aged 60-80 years). We modeled the relationships between CRF, PA, and brain functional integrity using multivariate partial least squares analysis. As an index of functional brain integrity we used spontaneous moment-to-moment variability in the blood oxygenation level-dependent signal (SDBOLD), known to be associated with better cognitive functioning in aging. We found that older adults who engaged more in LI-PA and MV-PA had greater SDBOLD in brain regions that play a role in integrating segregated functional domains in the brain and benefit from greater CRF or PA, such as precuneus, hippocampus, medial and lateral prefrontal, and temporal cortices. Our results suggest that engaging in higher intensity PA may have protective effects on neural processing in aging. Finally, we demonstrated that older adults with greater overall WM microstructure were those showing more LI-PA and MV-PA and greater SDBOLD. We conclude that SDBOLD is a promising correlate of functional brain health in aging. Future analyses will evaluate whether SDBOLD is modifiable with interventions aimed to increase PA and CRF in older adults.
Details
- Title: Subtitle
- Physical Activity Is Linked to Greater Moment-To-Moment Variability in Spontaneous Brain Activity in Older Adults
- Creators
- Agnieszka Z Burzynska - The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of AmericaChelsea N Wong - The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of AmericaMichelle W Voss - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, United States of AmericaGillian E Cooke - The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of AmericaNeha P Gothe - Department of Kinesiology, Health and Sport Studies, Wayne State University, Detroit, MI, United States of AmericaJason Fanning - Department of Kinesiology and Community Health, University of Illinois, Urbana, IL, United States of AmericaEdward McAuley - Department of Kinesiology, Health and Sport Studies, Wayne State University, Detroit, MI, United States of AmericaArthur F Kramer - The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(8), pp.e0134819-e0134819
- DOI
- 10.1371/journal.pone.0134819
- PMID
- 26244873
- PMCID
- PMC4526228
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- United States
- Grant note
- R37-AG025667 / NIA NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984002360002771
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