Journal article
Physical Exercise Restores Microvascular Function in Obese Rats with Metabolic Syndrome
Metabolic syndrome and related disorders, Vol.12(9), pp.484-492
11/01/2014
DOI: 10.1089/met.2014.0040
PMID: 25137183
Abstract
Background: Obesity and metabolic syndrome are related to systemic functional microvascular alterations, including a significant reduction in microvessel density. The aim of this study was to investigate the effects of exercise training on functional capillary density in the skeletal muscle and skin of obese rats with metabolic syndrome.
Methods: We used male Wistar-Kyoto rats that had been fed a standard commercial diet (CON) or high-fat diet (HFD) for 32 weeks. Animals receiving the HFD were randomly divided into sedentary (HFD+SED) and training groups (HFD+TR) at the 20(th) week. After 12 weeks of aerobic treadmill training, the maximal oxygen uptake (VO(2)max); hemodynamic, biochemical, and anthropometric parameters; and functional capillary density were assessed. In addition, a maximal exercise test was performed.
Results: Exercise training increased the VO(2)max (69 +/- 3 mL/kg per min) and exercise tolerance (30 +/- 1 min) compared with the HFD+SED (41 +/- 6 mL/kg per min, P<0.05 and 16 +/- 1 min, P<0.001) and with the CON (52 +/- 7 mL/kg per min and 18 +/- 1 min, P<0.05) groups. The HFD+TR group also showed reduced retroperitoneal fat (0.03 +/- 0.00 vs. 0.05 +/- 0.00 gram/gram, P<0.001), epididymal fat (0.01 +/- 0.00 vs. 0.02 +/- 0.00 gram/gram, P<0.001), and systolic blood pressure (127 +/- 2 vs. 150 +/- 2 mmHg, P<0.001). The HFD+TR group also demonstrated improved glucose tolerance, as evaluated by an intraperitoneal glucose tolerance test, fasting plasma glucose levels (5.0 +/- 0.1 vs. 6.4 +/- 0.2 mmol/L, P<0.001) and fasting plasma insulin levels (26.5 +/- 2.3 vs. 38.9 +/- 3.7 mu IU/mL, P<0.05). Glucose tolerance did not differ between HFD+TR and CON groups. Exercise training also increased the number of spontaneously perfused capillaries in the skeletal muscle (252 +/- 9 vs. 207 +/- 9 capillaries/mm(2)) of the training group compared with that in the sedentary animals (260 +/- 15 capillaries/mm(2)).
Conclusions: These results demonstrate that exercise training reverses capillary rarefaction in our experimental model of metabolic syndrome and obesity.
Details
- Title: Subtitle
- Physical Exercise Restores Microvascular Function in Obese Rats with Metabolic Syndrome
- Creators
- Marcus Vinicius Machado - Fundação Oswaldo CruzAline Bomfim Vieira - Fundação Oswaldo CruzAlessandro Rodrigues Nascimento - Fundação Oswaldo CruzRomulo Lanza Martins - Fundação Oswaldo CruzJulio Beltrame Daleprane - Universidade do Estado do Rio de JaneiroMarcos Adriano Lessa - University of Iowa, AnesthesiaEduardo Tibirica - Fundação Oswaldo Cruz
- Resource Type
- Journal article
- Publication Details
- Metabolic syndrome and related disorders, Vol.12(9), pp.484-492
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/met.2014.0040
- PMID
- 25137183
- ISSN
- 1540-4196
- eISSN
- 1557-8518
- Number of pages
- 9
- Grant note
- Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) FAPERJ (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ)
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Anesthesia
- Record Identifier
- 9984656594402771
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