Journal article
Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
Osteoarthritis and cartilage, Vol.21(6), pp.789-795
06/2013
DOI: 10.1016/j.joca.2013.03.001
PMCID: PMC3648587
PMID: 23523851
Abstract
To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment.
We combined data from Multicenter Osteoarthritis (MOST) and Osteoarthritis Initiative (OAI), studies of persons with or at high risk of OA. Subjects had long limb and repeated posteroanterior knee radiographs and completed the physical activity survey for the elderly (PASE). We studied persons without radiographic OA and excluded knees with major injury and without long limb films. We followed subjects 30 months (in MOST) and 48 months (in OAI) for one of two incident outcomes: (1) symptomatic tibiofemoral OA (radiographic OA and knee pain), or (2) tibiofemoral narrowing. ‘Active’ persons were those with PASE score in the highest quartile by gender. We examined risk of OA in active group using logistic regression adjusting for age, gender, body mass index (BMI), Western Ontario and McMaster Arthritis Index (WOMAC) pain score, Kellgren and Lawrence (KL) grade (0 or 1), and study of origin. We also analyzed knees from malaligned and neutrally aligned limbs.
The combined sample comprised 2,073 subjects (3,542 knees) with mean age 61 years. The cumulative incidence of symptomatic tibiofemoral OA was 1.12% in the active group vs 1.82% in the others (odds ratio (OR) among active group 0.6, 95% confidence interval (CI) 0.3, 1.3). Joint space narrowing occurred in 3.41% of knees in the active group vs 4.04% in the others (OR among active group 0.9 (95% CI 0.5, 1.5)). Results did not differ by alignment status.
Physical activity in the highest quartile did not affect the risk of developing OA.
Details
- Title: Subtitle
- Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
- Creators
- J Torner - Department of Epidemiology at the University of Iowa, USAD.T Felson - Clinical Epidemiology Unit at Boston University School of Medicine, USAT Yang - Clinical Epidemiology Unit at Boston University School of Medicine, USAJ Niu - Clinical Epidemiology Unit at Boston University School of Medicine, USAC.E Lewis - Division of Preventive Medicine at University of Alabama, Birmingham, USAP Aliabadi - Department of Radiology at Brigham and Women's Hospital in Boston, USAB Sack - Clinical Epidemiology Unit at Boston University School of Medicine, USAL Sharma - Division of Rheumatology at Northwestern University, Feinberg School of Medicine, USAA Guermazi - Radiology at Boston University School of Medicine, USAJ Goggins - Clinical Epidemiology Unit at Boston University School of Medicine, USAM.C Nevitt - Department of Epidemiology and Biostatistics at University of California, San Francisco, USAMOST and OAI investigators
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.21(6), pp.789-795
- DOI
- 10.1016/j.joca.2013.03.001
- PMID
- 23523851
- PMCID
- PMC3648587
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 06/2013
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995176502771
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