Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Agnieszka Zofia Burzynska; Laura Chaddock-Heyman; Michelle W Voss; Chelsea N Wong; Neha P Gothe; Erin A Olson; Anya Knecht; Andrew Lewis; Jim M Monti; Gillian E Cooke; Thomas R Wojcicki; Jason Fanning; Hyondo David Chung; Elisabeth Awick; Edward McAuley; Arthur F Kramer

doi:10.1371/journal.pone.0107413

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Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Journal article

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Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Agnieszka Zofia Burzynska, Laura Chaddock-Heyman, Michelle W Voss, Chelsea N Wong, Neha P Gothe, Erin A Olson, Anya Knecht, Andrew Lewis, Jim M Monti, Gillian E Cooke, …

PloS one, Vol.9(9), pp.e107413-e107413

2014

DOI: 10.1371/journal.pone.0107413

PMCID: PMC4167864

PMID: 25229455

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Abstract

Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.

Physical Fitness

Life Style

Age Factors

Humans

Middle Aged

Male

Cognition

Sedentary Lifestyle

Motor Activity

Diffusion Tensor Imaging

Sex Factors

Female

Aged

White Matter - physiology

Details

Title: Subtitle: Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults
Creators: Agnieszka Zofia Burzynska - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Laura Chaddock-Heyman - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Michelle W Voss - Department of Psychology, University of Iowa, Iowa City, Iowa, United States of America
Chelsea N Wong - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Neha P Gothe - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Erin A Olson - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Anya Knecht - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Andrew Lewis - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Jim M Monti - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Gillian E Cooke - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Thomas R Wojcicki - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Jason Fanning - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Hyondo David Chung - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Elisabeth Awick - Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Edward McAuley - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America; Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, United States of America
Arthur F Kramer - The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
Resource Type: Journal article
Publication Details: PloS one, Vol.9(9), pp.e107413-e107413
DOI: 10.1371/journal.pone.0107413
PMID: 25229455
PMCID: PMC4167864
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: R37-AG025667 / NIA NIH HHS
Language: English
Date published: 2014
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002358902771

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