Journal article
Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis
International journal of cancer, Vol.152(3), pp.396-407
02/01/2023
DOI: 10.1002/ijc.34266
PMID: 36054546
Abstract
Non‐Hodgkin lymphoma (NHL) is composed of a heterogeneous collection of subtypes with considerable differences in genetics, biology and aetiology. Studies to date on physical activity and NHL risk have not had sufficient sample size to evaluate whether associations differ by subtype. We pooled data from nine case‐control studies to examine the association between moderate‐to‐vigorous intensity physical activity (MVPA) and risk of NHL overall and by subtype (diffuse large B‐cell lymphoma, follicular lymphoma, chronic lymphocytic leukaemia/small lymphocytic lymphoma, marginal zone lymphoma and mature T‐cell lymphoma). A total of 5653 cases and 9115 controls were included in the pooled analysis. Physical activity was harmonised across nine studies and modelled as study‐specific tertiles. Multinomial logistic regression was used to estimate the association between physical activity and NHL, adjusting for confounders. The overall odds of NHL was 13% lower among participants in the most active tertile of MVPA compared to the least active tertile (adjusted odds ratio = 0.87, 95% CI = 0.80, 0.95). Similar decreases were observed across NHL subtypes. In summary, in this pooled analysis of case‐control studies, physical activity was associated with a modest risk reduction for each NHL subtype examined and with overall NHL.
What's new?
Studies of the relationship between physical activity and non‐Hodgkin lymphoma (NHL) have not had the statistical power to address NHL's many subtypes. Here, the authors pooled data from nine studies to look for differential associations between activity and five NHL subtypes: diffuse large B‐cell lymphoma, follicular lymphoma, chronic lymphocytic leukaemia/small lymphocytic lymphoma, marginal zone lymphoma and mature T‐cell lymphoma. The most active study participants had a 13% reduction in overall risk of NHL, and similar reductions were seen for all five subtypes.
Details
- Title: Subtitle
- Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis
- Creators
- Terry Boyle - BC Cancer AgencyGeffen Kleinstern - University of HaifaPaige M. Bracci - University of California, San FranciscoJames R. Cerhan - Department of Health Sciences Research Mayo Clinic Rochester Minnesota United StatesYolanda Benavente - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaDelphine Casabonne - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaBrian C.‐H. Chiu - University of ChicagoThomas M. Habermann - Mayo ClinicElizabeth A. Holly - University of California, San FranciscoMark Liebow - Mayo Clinic in FloridaAaron Norman - Department of Health Sciences Research Mayo Clinic Rochester Minnesota United StatesOra Paltiel - Hebrew University of JerusalemDennis Robinson - Mayo ClinicNathaniel Rothman - National Cancer InstituteRania Abu Seir - Al-Quds UniversitySusan L. Slager - Mayo ClinicPaul J. Villeneuve - Carleton UniversitySophia S. Wang - City Of Hope National Medical CenterDennis D. Weisenburger - City Of Hope National Medical CenterJohn J. Spinelli - BC Cancer Agency
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.152(3), pp.396-407
- DOI
- 10.1002/ijc.34266
- PMID
- 36054546
- NLM abbreviation
- Int J Cancer
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 12
- Grant note
- National Health and Medical Research Council (1072266) California Department of Public Health American Institute for Cancer Research (99B083) Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública National Cancer Institute of Canada Instituto de Salud Carlos III (PMP15/00007) Agència de Gestió d'Ajuts Universitaris i de Recerca National Cancer Institute (N01‐PC‐67008; CA087014; CA143947; N01‐PC‐35136; N01‐PC‐65064; N01‐PC‐67009; N01‐PC‐67010; N02‐PC‐71105; P01 CA017054; P30 CA033572; P50 CA97274; R01 CA166219; R01 CA92153; R01CA033572; R01CA100555) Israel Science Foundation (877/10) CERCA Programme/Generalitat de Catalunya (2017SGR1085) Hadassah University Hospital Compensatory Fund Henry J. Predolin Foundation for Research in Leukemia Spanish Ministry of Economy and Competitiveness‐Carlos III Institute of Health co‐funded by FEDER funds/European Regional Development Fund (ERDF) (IJCI‐2016‐29502; PI09/1662; PI11/01810; PI11/02213; PI14/01219; PI15/00966; PI17/01280; RCESP C03/09; RD12/0036/0056; RTIC RD06/0020/0095; RTICESP C03/10; Rio Hortega CM13/00232; SV‐09‐CLINIC‐1) Canadian Institutes of Health Research (300068) Centers for Disease Control and Prevention (U55/CCR921930‐02) United States Agency for International Development (TA‐MOU‐11‐M31‐025) Michael Smith Foundation for Health Research (5553)
- Language
- English
- Date published
- 02/01/2023
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368080202771
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