Journal article
Physiologic changes associated with ligation of the ductus arteriosus in preterm infants
The Journal of pediatrics, Vol.101(5), pp.749-753
11/1982
DOI: 10.1016/S0022-3476(82)80311-9
PMID: 7131153
Abstract
Cardiorespiratory and transcutaneous oxygen monitors were used on 13 preterm neonates to examine physiologic changes during ductus arteriosus ligation. Transcutaneous oxygen decreased 30 seconds after left lung deflation; all infants required increases in inspired oxygen and ventilation to correct abnormal values after the left lung was compressed. Transcutaneous oxygen decreased 30 seconds after ductus arteriosus ligation (mean ΔtcPO2=-17 mm Hg±11.4) but increased 150 seconds after left lung inflation (mean ΔtcPO2=46.9 mm Hg±28.8). Arterial blood pressure increased (mean Δ systolic BP=17.9 mm Hg±9.5) and heart rate decreased 10 seconds after ductus arteriosus ligation. In five neonates, gradual closure of the ductus arteriosus over 40 to 75 seconds, resulted in a more gradual increase in blood pressure. Intraventricular hemorrhage was confirmed in two patients after surgery. Ligation of the ductus arteriosus results in an abrupt increase in blood pressure, which may be related to the pathogenesis of intraventricular hemorrhage. We suggest that the ductus arteriosus be closed gradually to allow a more gradual increase in blood pressure. © 1982 The C. V. Mosby Company.
Details
- Title: Subtitle
- Physiologic changes associated with ligation of the ductus arteriosus in preterm infants
- Creators
- Richard E. BehrmanTerry A. Marshall - Palmetto Health RichlandFoster Marshall - University of South CarolinaP. Prithvi Reddy - University of South Carolina
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.101(5), pp.749-753
- DOI
- 10.1016/S0022-3476(82)80311-9
- PMID
- 7131153
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Language
- English
- Date published
- 11/1982
- Academic Unit
- Preventive and Community Dentistry
- Record Identifier
- 9984367643702771
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