Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasia

Philip M Ullrich; Susan K Lutgendorf; Karl J Kreder

doi:10.1016/j.urology.2007.04.048

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Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasia

Journal article

Open access

Peer reviewed

Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasia

Philip M Ullrich, Susan K Lutgendorf and Karl J Kreder

Urology (Ridgewood, N.J.), Vol.70(3), pp.487-491

09/2007

DOI: 10.1016/j.urology.2007.04.048

PMCID: PMC2084069

PMID: 17905102

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Abstract

The sympathetic nervous system and hypothalamic-pituitary-gonadal axis are involved in the pathophysiology of benign prostatic hyperplasia (BPH). The sympathetic nervous system and hypothalamic-pituitary-gonadal axis are also highly reactive to psychological stressors, yet associations between prostate function and reactivity to a psychological stressor have not been examined using standardized psychological stress paradigms. The objective of this study was to examine the associations between psychological stress reactivity and BPH disease parameters. A total of 83 men diagnosed with BPH completed a standardized laboratory stress task, yielding measures of blood pressure, testosterone, and cortisol reactivity. Links were examined between stress reactivity (as indicated by changes in blood pressure, testosterone, and cortisol during the stress task) and measures of BPH disease, including prostate volume, postvoid residual bladder volume, urine flow rate, self-reported lower urinary tract symptoms, and impact and bother scores. In equations controlling for BPH medications, body mass index, and age, greater diastolic blood pressure reactivity was associated with a greater transition zone volume (P <0.001), greater total prostate gland volume (P <0.05), greater postvoid residual bladder volume (P <0.05), more severe lower urinary tract symptoms (P <0.001), and greater impact scores (P <0.05). Greater cortisol reactivity was associated with greater bother (P <0.05) and impact (P <0.001) scores. Physiologic reactivity to a standardized laboratory stressor is associated with objective and subjective BPH disease parameters. These findings contribute to growing data suggesting that stress conditions could be associated with the development or aggravation of prostatic disease.

Blood Pressure

Prostatic Hyperplasia - psychology

Humans

Middle Aged

Male

Saliva - chemistry

Sympathetic Nervous System - physiopathology

Urinary Bladder - pathology

Prostatic Hyperplasia - complications

Prostate - pathology

Doxazosin - therapeutic use

Stress, Psychological - metabolism

Ultrasonography

Hypothalamo-Hypophyseal System - physiopathology

Prostatic Hyperplasia - drug therapy

Pituitary-Adrenal System - physiopathology

Randomized Controlled Trials as Topic - statistics & numerical data

Urination Disorders - psychology

Organ Size

Prostatic Hyperplasia - metabolism

Prostate - diagnostic imaging

Testosterone - analysis

Urination Disorders - etiology

Hydrocortisone - analysis

Aged

Finasteride - therapeutic use

Prostatic Hyperplasia - physiopathology

Stress, Psychological - complications

Stress, Psychological - physiopathology

Details

Title: Subtitle: Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasia
Creators: Philip M Ullrich - Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA. pullrich@u.washington.edu
Susan K Lutgendorf
Karl J Kreder
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.70(3), pp.487-491
DOI: 10.1016/j.urology.2007.04.048
PMID: 17905102
PMCID: PMC2084069
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Publisher: United States
Grant note: U01 DK049971-06 / NIDDK NIH HHS DK49971 / NIDDK NIH HHS
Language: English
Date published: 09/2007
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065772502771

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