Journal article
Physiological Approach to Sodium Supplementation in Preterm Infants
American journal of perinatology, Vol.35(10), pp.994-1000
08/2018
DOI: 10.1055/s-0038-1632366
PMCID: PMC6059989
PMID: 29486497
Abstract
Abstract
Objective
To implement and evaluate a clinical practice algorithm to identify preterm infants with sodium deficiency and guide sodium supplementation based on urine sodium concentrations.
Study Design
Urine sodium concentration was measured in infants born at 26
0/7
to 29
6/7
weeks' gestation at 2-week intervals. Sodium supplementation was based on the urine sodium algorithm. Growth and respiratory outcomes in this cohort were compared with a matched cohort cared for in our neonatal intensive care unit prior to algorithm implementation (2014–2015 cohort).
Results
Data were compared for 50 infants in the 2014–2015 cohort and 40 infants in the 2016 cohort. Urine sodium concentration met criteria for supplementation in 75% of the 2016 cohort infants within the first 4 weeks after birth. Average daily sodium intake was greater in the 2016 cohort compared with the 2014–2015 cohort (
p
< 0.05). Caloric, protein, and total fluid intakes were similar between cohorts. The change in weight Z-score between 2 and 8 weeks of age was significantly greater in the 2016 versus 2014–2015 cohort (0.32 ± 0.05 vs. –0.01 ± 0.08;
p
< 0.01). No impact on respiratory status at 28 days of age or 36 weeks of postmenstrual age was identified.
Conclusion
Institution of a clinical practice algorithm to instruct clinicians on sodium supplementation in preterm infants may improve growth outcomes.
Details
- Title: Subtitle
- Physiological Approach to Sodium Supplementation in Preterm Infants
- Creators
- David E Segar - Stead Family Department of Pediatrics, Carver College of Medicine, University of IowaElizabeth K Segar - Stead Family Department of Pediatrics, Carver College of Medicine, University of IowaLyndsay A Harshman - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IowaJohn M Dagle - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IowaSusan J Carlson - Department of Food and Nutritional Services, University of Iowa Stead Family Children's Hospital, Iowa City, IowaJeffrey L Segar - Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of perinatology, Vol.35(10), pp.994-1000
- DOI
- 10.1055/s-0038-1632366
- PMID
- 29486497
- PMCID
- PMC6059989
- NLM abbreviation
- Am J Perinatol
- ISSN
- 0735-1631
- eISSN
- 1098-8785
- Publisher
- Thieme Medical Publishers; 333 Seventh Avenue, New York, NY 10001, USA
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9984024501302771
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