Journal article
Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line
Journal of perinatology, Vol.45(10), pp.1327-1334
10/2025
DOI: 10.1038/s41372-025-02407-w
PMID: 40903567
Abstract
Dopamine has been widely used as a first-line cardiovascular agent in neonatal intensive care units (NICUs) for the management of hypotension and circulatory support. While its effectiveness in increasing blood pressure is established, its potential effects on pulmonary vascular resistance, myocardial function, and overall hemodynamics require further consideration. This review explores the role of dopamine in neonatal hemodynamic management and considers alternative vasoactive agents tailored to specific pathophysiological conditions. A more individualized, physiology-based approach to cardiovascular support in neonates may help optimize treatment strategies.
Details
- Title: Subtitle
- Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line
- Creators
- Audrey Hébert - Université LavalSatyan Lakshminrusimha - UC Davis Children's HospitalDanielle R Rios - University of Iowa Stead Family Children’s HospitalShazia Bhombal - Children's Healthcare of AtlantaShiran Sara Moore - Tel Aviv Sourasky Medical CenterStephanie Ford - Rainbow Babies & Children's HospitalGabriel Altit - McGill University Health Centre
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.45(10), pp.1327-1334
- DOI
- 10.1038/s41372-025-02407-w
- PMID
- 40903567
- NLM abbreviation
- J Perinatol
- ISSN
- 1476-5543
- eISSN
- 1476-5543
- Publisher
- SPRINGERNATURE
- Language
- English
- Electronic publication date
- 09/04/2025
- Date published
- 10/2025
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984958290802771
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