Journal article
Pilot Study of Improved Lesion Characterization in Breast MRI Using a 3D Radial Balanced SSFP Technique With Isotropic Resolution and Efficient Fat-Water Separation
Journal of magnetic resonance imaging, Vol.30(1), pp.135-144
07/01/2009
DOI: 10.1002/jmri.21807
PMCID: PMC3743726
PMID: 19557728
Abstract
Purpose: To assess a 3D radial balanced steady-state free precession (SSFP) technique that provides submillimeter isotropic resolution and inherently registered fat and water image volumes in comparison to conventional T2-weighted RARE imaging for lesion characterization in breast magnetic resonance imaging (MRI).
Materials and Methods: 3D projection SSFP (3DPR-SSFP) combines a dual half-echo radial k-space trajectory with a linear combination fat/water separation technique (linear combination SSFP). A pilot study was performed in 20 patients to assess fat suppression and depiction of lesion morphology using 3DPR-SSFP. For all patients fat suppression was measured for the 3DPR-SSFP image volumes and depiction of lesion morphology was compared against corresponding T2-weighted, fast spin echo (FSE) datasets for 15 lesions in 11 patients.
Results: The isotropic 0.63 mm resolution of the 3DPR-SSFP sequence demonstrated improved depiction of lesion morphology in comparison to FSE. The 3DPR-SSFP fat and water datasets were available in a 5-minute scan time while average fat suppression with 3DPR-SSFP was 71% across all 20 patients.
Conclusion: 3DPR-SSFP has the potential to improve the lesion characterization information available in breast MRI, particularly in comparison to conventional FSE. A larger study is warranted to quantify the effect of 3DPR-SSFP on specificity.
Details
- Title: Subtitle
- Pilot Study of Improved Lesion Characterization in Breast MRI Using a 3D Radial Balanced SSFP Technique With Isotropic Resolution and Efficient Fat-Water Separation
- Creators
- Catherine J. Moran - University of Wisconsin–MadisonFrederick Kelcz - University of Wisconsin–MadisonYoungkyoo Jung - University of California, San DiegoEthan K. Brodsky - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonWalter F. Block - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.30(1), pp.135-144
- Publisher
- Wiley
- DOI
- 10.1002/jmri.21807
- PMID
- 19557728
- PMCID
- PMC3743726
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 10
- Grant note
- R01CA116380 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Coulter Translational Research Partnership 5T32 CA09206-31 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1RO1CA116380 / National Cancer Institute (NCI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 07/01/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274956202771
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